Characters who either originated or regularly appear in video games.
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- A.K.I.
- Aarbron
- Abbi (OMORI)
- Abby Anderson
- Abdonis (Ring Fit Adventure)
- Abe (Oddworld)
- Abel (The Walking Dead)
- Abiorugu
- Abobo
- Abomination (Ultimate Destruction)
- Abraham Gray
- Absalom (Darksiders)
- Absol
- Absolix
- Absolver
- Abstract Daddy
- Abyss (Marvel vs. Capcom)
- Abyss Herald
- Abyss Mage
- Abyssia
- Acheron (Honkai: Star Rail)
- Achi
- Achilles (SMITE)
- Acorn
- Ada Wong
- Adam Jensen (Deus Ex)
- Adam MacIntyre
- Adam Smasher
- Adam Taurus
- Adan, Thief of Fire
- Adanti (Shadow Fight)
- Addled Frog
- Adeleine
- Adrian (Versus Umbra)
- Adrian Shephard
- Adéwalé
- Aegis (AEverse)
- Aegislash
- Aerith Gainsborough
- Aero-Chaser
- Afeera
- Agamemnon (Assassin's Creed)
- Agamo
- Aganos
- Agatha (Dark Deception)
- Agatha Knife (Character)
- Agent 9 (Spyro)
- Agnaktor
- Agni (SMITE)
- Agrippa
- Ah Muzen Cab (SMITE)
- Ah Puch (SMITE)
- Ah-Kin (Kingdom of Arcadia)
- Aha (Honkai: Star Rail)
- Ahriman (Shin Megami Tensei)
- Aht
- AiAi
- Aiden Pearce
- Air Man
- Air Screamer
- Airan Jo
- Aisha (Metamorphy Path)
- Aiwhen (Wonderful World)
- Ajax
- Ajax (The Warriors)
- Aka
- Akane Owari
- Akane Sugahara
- Akantor
- Akari
- Aki (Misao)
- Akihiko Sanada
- Akira (The Silver Case)
- Akira Howard
- Akira Kazama
- Akira Nishikiyama
- Akira Shinobu
- Akira Yuki
- Akriloth
- Akuma (Marvel vs. Capcom)
- Akuma (Power Rangers)
- Akuma (Street Fighter)
- Akuma (Tekken)
- Al Mualim (Assassin's Creed)
- Aladdin (Kingdom Hearts)
- Alaic
- Alakazam
- Alastor (Viewtiful Joe)
- Alatreon
- Albedo (Genshin Impact)
- Albert King (Arkham Series)
- Albert Wesker
- Albert Wesker (Marvel vs. Capcom)
- Albus Dumbledore (Lego)
- Alcina Dimitrescu
- Alcremie
- Aldebaran (Puzzle and Dragons)
- Alduin
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- Alex Eggleston (Cross Impact)
- Alex Kidd
- Alex Mason
- Alex Mercer
- Alex Roivas
- Alexia Ashford
- Alfis (Piggy)
- Alfonse
- Alfonse (Dragalia Lost)
- Alfred (Curse of the Moon)
- Alfred (Ritual of the Night)
- Alfred, Hunter of Vilebloods
- Alfyn Greengrass
- Algomon
- Algérie (Azur Lane)
- Alia
- Alice (Grimlight)
- Alice (Mobile Legends)
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- Alice Angel
- Alice Yabusame
- Alien (Mortal Kombat)
- Alien (Streets of Rogue)
- Alien Train Tank
- Aliens (Galaga)
- Alina Gray
- Alis Landale
- Alisa Bosconovitch
- Alissa Cyan
- Allegra (Ring Fit Adventure)
- Allen O'Neil
- Allen Snider
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- Alligator (Resident Evil)
- Allison Angel
- Allosaurus (Carnivores)
- Alm (Fire Emblem)
- Almalexia
- Alonso (ActRaiser)
- Aloy
- Alpha (Velgress)
- Alpha Gang Trio
- Alphadon (Carnivores)
- Alphonse
- Alriune
- Altaïr Ibn-La'Ahad
- Alter (Apex Legends)
- Alter Ego (Okita Alter)
- Alucard (Castlevania)
- Alucard (Lords of Shadow)
- Alvin Jr. (The Walking Dead)
- Alys Brangwin
- Amadeus Syndicate
- Amanda O'Neill
- Amanda Ripley
- Amaterasu (Marvel vs. Capcom)
- Amaterasu (Ōkami)
- Amatsu
- Amazing Spider-Man (Shattered Dimensions)
- Amber (Genshin Impact)
- Amelia (Khimera)
- Amingo
- Amitie (Puyo Puyo)
- Amorges (Assassin's Creed)
- Amy Rose (Game)
- Amygdala
- Ana (Overwatch)
- Anakaris
- Anakaris (Marvel vs. Capcom)
- Anakin Skywalker (Lego Star Wars)
- Anankos
- Anarky (Arkham Series)
- Anax
- Anchovy
- Ancient (Shadow Fight)
- Ancient Dragonknight Kristoff
- Ancient Leshen (Monster Hunter)
- Ancient One (Octopath Traveler)
- Andre Richardson
- Andrew Graves
- Andrewsarchus (Carnivores)
- Andrius
- André (Rayman)
- Anduin Lothar
- Andy (Advance Wars)
- Andy (Heart of Darkness)
- Andy Bogard (Fatal Fury)
- Andy Bogard (The King of Fighters)
- Angel of Light and Shadow
- Angelan (Toaru x Virtual On Crossover)
- Angelus (Drakengard)
- Angie Yonaga
- Angra
- Angus Bumby (Alice : Madness Returns)
- Anhur (SMITE)
- Anita (Marvel vs. Capcom)