Neurotenzinski receptor

Sortilin 1
Identifikatori
Simbol	SORT1
Alt. simboli	Gp95, NT3
Entrez	6272
HUGO	11186
OMIM	602458
RefSeq	NM_002959
UniProt	Q99523
Drugi podaci
Lokus	Hromozom 1 p21.3-1p13.1

Neurotenzinski receptor 2
Identifikatori
Simbol	NTSR2
Alt. simboli	NTR2
Entrez	23620
HUGO	8040
OMIM	605538
RefSeq	NM_012344
UniProt	O95665
Drugi podaci
Lokus	Hromozom 2 p25.1

Neurotenzinski receptor 1
Identifikatori
Simbol	NTSR1
Alt. simboli	NTR
Entrez	4923
HUGO	8039
OMIM	162651
RefSeq	NM_002531
UniProt	P30989
Drugi podaci
Lokus	Hromozom 20 q13-20q13

Neurotenzinski receptori su GPCR transmembranski receptori koji vezuju neurotransmiter neurotenzin.^[1]^[2] Dva od ovih receptora su kodirana genima NTSR1 i NTSR2, i sadrže sedam transmembranskih heliksa. Treći receptor poseduje jedan transmembranski domen i kodiran je SORT1 genom.

Ligandi

Agonisti

Peptidni

Beta-laktotenzin (NTS₂ selektivni)^[3]
JMV-449
Neurotenzin
Neuromedin N (NTS₁ selektivni)
PD-149,163 (NTS₁ selektivni)

Ne-peptidni

Parcijalni agonisti izvedeni iz SR-48692^[4]

Antagonisti

Levokabastin (NTS₂ selektivan, takođe antagonist H₁ histaminskog receptora)^[5]
SR-48692 (NTS₁ selektivan)^[6]
SR-142,948 (neselektivan, CAS# 184162-64-9)

Literatura

↑ Vincent JP, Mazella J, Kitabgi P (1999). „Neurotensin and neurotensin receptors”. Trends Pharmacol. Sci. 20 (7): 302–9. DOI:10.1016/S0165-6147(99)01357-7. PMID 10390649.
↑ Pelaprat D (2006). „Interactions between neurotensin receptors and G proteins”. Peptides 27 (10): 2476–87. DOI:10.1016/j.peptides.2006.04.027. PMID 16919370.
↑ Yamauchi R, Usui H, Yunden J, Takenaka Y, Tani F, Yoshikawa M (April 2003). „Characterization of beta-lactotensin, a bioactive peptide derived from bovine beta-lactoglobulin, as a neurotensin agonist”. Bioscience, Biotechnology, and Biochemistry 67 (4): 940–3. PMID 12784648.
↑ Thomas JB, Navarro H, Warner KR, Gilmour B (March 2009). „The identification of nonpeptide neurotensin receptor partial agonists from the potent antagonist SR48692 using a calcium mobilization assay”. Bioorganic & Medicinal Chemistry Letters 19 (5): 1438–41. DOI:10.1016/j.bmcl.2009.01.024. PMID 19195889.
↑ Bredeloux P, Costentin J, Dubuc I (December 2006). „Interactions between NTS2 neurotensin and opioid receptors on two nociceptive responses assessed on the hot plate test in mice”. Behavioural Brain Research 175 (2): 399–407. DOI:10.1016/j.bbr.2006.09.016. PMID 17074405.
↑ Ferraro L, Tomasini MC, Mazza R, Fuxe K, Fournier J, Tanganelli S, Antonelli T (August 2008). „Neurotensin receptors as modulators of glutamatergic transmission”. Brain Research Reviews 58 (2): 365–73. DOI:10.1016/j.brainresrev.2007.11.001. PMID 18096238.

Spoljašnje veze

„Neurotensin Receptors”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.
MeSH Neurotensin+Receptors

[pmid10390649-1] Vincent JP, Mazella J, Kitabgi P (1999). „Neurotensin and neurotensin receptors”. Trends Pharmacol. Sci. 20 (7): 302–9. DOI:10.1016/S0165-6147(99)01357-7. PMID 10390649.

[pmid16919370-2] Pelaprat D (2006). „Interactions between neurotensin receptors and G proteins”. Peptides 27 (10): 2476–87. DOI:10.1016/j.peptides.2006.04.027. PMID 16919370.

[pmid12784648-3] Yamauchi R, Usui H, Yunden J, Takenaka Y, Tani F, Yoshikawa M (April 2003). „Characterization of beta-lactotensin, a bioactive peptide derived from bovine beta-lactoglobulin, as a neurotensin agonist”. Bioscience, Biotechnology, and Biochemistry 67 (4): 940–3. PMID 12784648.

[pmid19195889-4] Thomas JB, Navarro H, Warner KR, Gilmour B (March 2009). „The identification of nonpeptide neurotensin receptor partial agonists from the potent antagonist SR48692 using a calcium mobilization assay”. Bioorganic & Medicinal Chemistry Letters 19 (5): 1438–41. DOI:10.1016/j.bmcl.2009.01.024. PMID 19195889.

[pmid17074405-5] Bredeloux P, Costentin J, Dubuc I (December 2006). „Interactions between NTS2 neurotensin and opioid receptors on two nociceptive responses assessed on the hot plate test in mice”. Behavioural Brain Research 175 (2): 399–407. DOI:10.1016/j.bbr.2006.09.016. PMID 17074405.

[pmid18096238-6] Ferraro L, Tomasini MC, Mazza R, Fuxe K, Fournier J, Tanganelli S, Antonelli T (August 2008). „Neurotensin receptors as modulators of glutamatergic transmission”. Brain Research Reviews 58 (2): 365–73. DOI:10.1016/j.brainresrev.2007.11.001. PMID 18096238.

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