GPR34
| edit |
| G protein-spregnuti receptor 34 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | GPR34; | ||||||||||
| Vanjski ID | OMIM: 300241 MGI: 1346334 HomoloGene: 36174 IUPHAR: GPR34 GeneCards: GPR34 Gene | ||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 2857 | 23890 | |||||||||
| Ensembl | ENSG00000171659 | ENSMUSG00000040229 | |||||||||
| UniProt | Q9UPC5 | Q3USC5 | |||||||||
| RefSeq (mRNA) | NM_001033513 | NM_011823 | |||||||||
| RefSeq (protein) | NP_001028685 | NP_035953 | |||||||||
| Lokacija (UCSC) | Chr X: 41.43 - 41.44 Mb | Chr X: 12.79 - 12.8 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
GPR34, G protein-spregnuti receptor 34, je protein koji je kod čoveka kodiran GPR34 genom.[1][2][3]
G protein-spregnuti receptori, kao što je GPR34, su integralni membranski proteini koji sadrže 7 transmembranskih domaina (TM). Ti proteini prenose signale u unutrašnjost ćelije putem aktivacije heterotrimernih G proteina koji zatim aktiviraju razne efektorske proteine, što ultimatno dovodi do fiziološkog responsa.[3]
- ↑ Schoneberg T, Schulz A, Grosse R, Schade R, Henklein P, Schultz G, Gudermann T (Aug 1999). „A novel subgroup of class I G-protein-coupled receptors”. Biochim Biophys Acta 1446 (1-2): 57–70. PMID 10395919.
- ↑ Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF (May 1999). „Discovery of three novel orphan G-protein-coupled receptors”. Genomics 56 (1): 12–21. DOI:10.1006/geno.1998.5655. PMID 10036181.
- ↑ 3,0 3,1 „Entrez Gene: GPR34 G protein-coupled receptor 34”.
- Hillier LD, Lennon G, Becker M, et al. (1997). „Generation and analysis of 280,000 human expressed sequence tags.”. Genome Res. 6 (9): 807–28. DOI:10.1101/gr.6.9.807. PMID 8889549.
- Jacobi FK, Broghammer M, Pesch K, et al. (2000). „Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1.”. Hum. Genet. 107 (1): 89–91. DOI:10.1007/s004390050017. PMID 10982042.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Otsuki T, Ota T, Nishikawa T, et al. (2007). „Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.”. DNA Res. 12 (2): 117–26. DOI:10.1093/dnares/12.2.117. PMID 16303743.
- Engemaier E, Römpler H, Schöneberg T, Schulz A (2006). „Genomic and supragenomic structure of the nucleotide-like G-protein-coupled receptor GPR34.”. Genomics 87 (2): 254–64. DOI:10.1016/j.ygeno.2005.10.001. PMID 16338117.
- Oh JH, Yang JO, Hahn Y, et al. (2006). „Transcriptome analysis of human gastric cancer.”. Mamm. Genome 16 (12): 942–54. DOI:10.1007/s00335-005-0075-2. PMID 16341674.