Eikozanoidni receptor
Eikozanoidni receptor je integralni membranski protein koji detektuje prisustvo eikozanoidnih signalnih molekula. Većina, mada ne svi, su G protein spregnuti receptori. Primer ne-GPCR receptora koji vezuje eikozanoide je PPAR-γ.[1]
Ovo su poznati humani eikozanoidni GPCR receptori grupisani po tipu eikozanoidnog liganda koji vezuju:[2][3]
- CysLT1 (Cisteinil leukotrienski receptor 1) - CYSLTR1
- CysLT2 (Cisteinil leukotrienski receptor 2) - CYSLTR2
- BLT1 (Leukotrienski B4 receptor) - LTB4R
- BLT2 (Leukotrienski B4 receptor 2) - LTB4R2
- LXA4R (Formil peptidnom receptoru-sličan 1) - FPRL1
- PGD2: DP-(PGD2)
- DP1 (Prostaglandin D2 receptor) - PTGDR
- DP2 (GPR44) - GPR44
- PGE2:
- PGF2α: FP-(PGF2α) (PTGFR) - PTGFR
- PGI2 (prostaciklin): IP-(PGI2) (PTGIR) - PTGIR
- TXA2 (tromboksan): TP-(TXA2) (TBXA2R) - TBXA2R
- ↑ DuBois RN, Gupta R, Brockman J, Reddy BS, Krakow SL, Lazar MA (1998). „The nuclear eicosanoid receptor, PPAR-γ, is aberrantly expressed in colonic cancers”. Carcinogenesis 19 (1): 49–53. DOI:10.1093/carcin/19.1.49. PMID 9472692.
- ↑ Coleman RA, Smith WL, Narumiya S (1994). „International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes”. Pharmacol. Rev. 46 (2): 205–29. PMID 7938166.
- ↑ Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Nicosia S, Serhan CN, Shimizu T, Yokomizo T (2003). „International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors”. Pharmacol. Rev. 55 (1): 195–227. DOI:10.1124/pr.55.1.8. PMID 12615958.
- ↑ Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Rovati GE, Serhan CN, Shimizu T, Yokomizo T (2004). „International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor”. Pharmacol. Rev. 56 (1): 149–57. DOI:10.1124/pr.56.1.4. PMID 15001665.
- „Leukotriene Receptors”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.
- „Prostanoid Receptors”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2021-04-15.
- MeSH Eicosanoid+receptors