Domperidon

Domperidon
(IUPAC) ime
	5-hloro-1-(1-[3-(2-okso-2,3-dihidro-1H-benzo[d]imidazol-1-il)propil]piperidin-4-il)-1H-benzo[d]imidazol-2(3H)-on
Klinički podaci
Robne marke	Motilijum
AHFS/Drugs.com	Mikromedeks, detaljne potrošačke informacije
Identifikatori
CAS broj	57808-66-9
ATC kod	A03FA03 QP51AX24
PubChem	3151
DrugBank	APRD00418
ChemSpider	3039
UNII	5587267Z69
KEGG	D01745
ChEBI	CHEBI:31515
ChEMBL	CHEMBL219916
Hemijski podaci
Formula	C22H24ClN5O2
Mol. masa	425,911 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30) ; Key: FGXWKSZFVQUSTL-UHFFFAOYSA-N
Farmakokinetički podaci
Bioraspoloživost	Visoka
Vezivanje za proteine plazme	91–93%
Metabolizam	Hepatički i intestinalno (prvi prolaz)
Poluvreme eliminacije	7 sati
Izlučivanje	Laktacija, renalno
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	Nije odobren u SAD-u; samo na recepat: Indija, Australija, Kanada, Izrael
Način primene	Oralno, intravenozno, rektalno

Domperidon (Motilijum, Motinorm i Costi) je antidopaminergični lek, koji je razvila kompanija Jansen farmaceutika. On se koristi oralno, rektalno ili intravenozno. Domperidon se upotrebljava za suzbijanje mučnine i povraćanja, kao prokinetički agens i za stimulaciju laktacije.^[7]^[8]

Farmakologija

Domperidon blokira dejstvo dopamina. On ima jak afinitet za D₂ i D₃ dopaminske receptore^[9]

Povezano

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Domperidone Arhivirano 2013-05-22 na Wayback Machine-u MedSafe NZ Government
↑ Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7.
↑ Pdr Staff (2009). PDR: Physicians Desk Reference 2010 (Physicians' Desk Reference (Pdr)). Rozelle, N.S.W: Thomson Reuters. ISBN 1-56363-748-0.
↑ „PDSP Ki Database”. Arhivirano iz originala na datum 2013-11-08. Pristupljeno 2014-04-05.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] Domperidone Arhivirano 2013-05-22 na Wayback Machine-u MedSafe NZ Government

[Goodman_Gilman-7] Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7.

[PDR-8] Pdr Staff (2009). PDR: Physicians Desk Reference 2010 (Physicians' Desk Reference (Pdr)). Rozelle, N.S.W: Thomson Reuters. ISBN 1-56363-748-0.

[9] „PDSP Ki Database”. Arhivirano iz originala na datum 2013-11-08. Pristupljeno 2014-04-05.

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