Nikotinamid

Nikotinamid
	piridin-3-karboksamid
Drugi nazivi	3-piridinkarboksamid; niacinamid; amid nikotinske kiseline; Vitamin PP
Identifikacija
CAS registarski broj	98-92-0
PubChem	936
ChemSpider	911
UNII	25X51I8RD4
EINECS broj	202-713-4
DrugBank	DB02701
KEGG	D00036
ChEBI	17154
ChEMBL	CHEMBL1140
ATC code	A11HA01
Jmol-3D slike	Slika 1
SMILES
	c1cc(cnc1)C(=O)N
InChI
	InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) ; Kod: DFPAKSUCGFBDDF-UHFFFAOYSA-N InChI=1/C6H6N2O/c7-6(9)5-2-1-3-8- 4-5/h1-4H,(H2,7,9)/f/h7H2 InChI=1/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9); Kod: DFPAKSUCGFBDDF-UHFFFAOYAZ
Svojstva
Molekulska formula	C6H6N2O
Molarna masa	122.12 g mol−1
Tačka topljenja	128-131 °C
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Nikotinamid (niacinamid) je amid nikotinske kiseline (vitamin B₃ / niacin). Nikotinamid je u vodi rastvorni vitamin i deo je grupe vitamina B. Nikotinska kiselina, takođe poznata kao niacin, se konvertuje do nikotinamida in vivo, i mada su ova dva jedinjenja identična u pogledu njihovih vitaminskih funkcija, nikotinamid nema ista farmakološka i toksična dejstva kao niacin. Nikotinamid ne redukuje holesterol, niti uzrokuje crvenilo.^[6] On može da bude toksičan za jetru pri dozama iznad 3 g/dan kod odraslih.^[7] U ćelijama, niacin je inkorporiran u nikotinamid adenin dinukleotid (NAD) i nikotinamid adenin dinukleotid fosfat (NADP). Metabolički putevi za nikotinamid i nikotinsku kiselinu su veoma slični. NAD+ i NADP+ su koenzimi u velikom broju enzimatskih oksidaciono-redukcionih reakcija.^[8] Nikotinamid se formira u vodenoj aminolizi 3-cijanopiridina (nikotinonitrila) i naknadnom kristalizacijom.

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes �� KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Jacenollo, P. (1992). Niacin versus niacinamide Arhivirano 2019-06-19 na Wayback Machine-u
↑ Knip M, Douek IF, Moore WP i dr.. (2000). „Safety of high-dose nicotinamide: a review”. Diabetologia 43 (11): 1337–45. DOI:10.1007/s001250051536. PMID 11126400.
↑ Belenky P; Bogan KL, Brenner C (2007). „NAD+ metabolism in health and disease”. Trends Biochem. Sci. 32 (1): 12–9. DOI:10.1016/j.tibs.2006.11.006. PMID 17161604. Pristupljeno 2007-12-23.

Povezano

Spoljašnje veze

DrugBank.ca Drug Card for Nicotinamide

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes �� KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] Jacenollo, P. (1992). Niacin versus niacinamide Arhivirano 2019-06-19 na Wayback Machine-u

[Knip_M,_Douek_IF,_Moore_WP,_et_al._2000_1337–45-7] Knip M, Douek IF, Moore WP i dr.. (2000). „Safety of high-dose nicotinamide: a review”. Diabetologia 43 (11): 1337–45. DOI:10.1007/s001250051536. PMID 11126400.

[Belenky-8] Belenky P; Bogan KL, Brenner C (2007). „NAD+ metabolism in health and disease”. Trends Biochem. Sci. 32 (1): 12–9. DOI:10.1016/j.tibs.2006.11.006. PMID 17161604. Pristupljeno 2007-12-23.

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