Levobunolol

Levobunolol
(IUPAC) ime
	(S)-5[3-(tert-butilamino)-2-hidroksipropil]oksi3,4-dihidronaftalen-1(2H)-on
Klinički podaci
Robne marke	Betagan
AHFS/Drugs.com	Monografija
MedlinePlus	a686011
Identifikatori
CAS broj	47141-42-4
ATC kod	S01ED03
PubChem	39468
DrugBank	DB01210
ChemSpider	36089
UNII	G6317AOI7K
KEGG	D08115
ChEBI	CHEBI:6438
ChEMBL	CHEMBL1201237
Hemijski podaci
Formula	C17H25NO3
Mol. masa	291,385 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C17H25NO3/c1-17(2,3)18-10-12(19)11-21-16-9-5-6-13-14(16)7-4-8-15(13)20/h5-6,9,12,18-19H,4,7-8,10-11H2,1-3H3/t12-/m0/s1 ; Key: IXHBTMCLRNMKHZ-LBPRGKRZSA-N
Farmakokinetički podaci
Poluvreme eliminacije	20 sata
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	℞-only (SAD)
Način primene	Topikalno (kapi za oči)

Levobunolol (AK-Beta, Liquifilm, Betegan) je neselektivni beta blokator. On se koristi topikalno za tretiranje glaukoma.

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

Ishibashi T, Yokoi N, Kinoshita S (2003). „Comparison of the effects of topical levobunolol and timolol solution on the human ocular surface.”. Cornea 22 (8): 709–15. DOI:10.1097/00003226-200311000-00001. PMID 14576520.
Ogasawara H, Yoshida A, Fujio N, Konno S, Ishiko S (1999). „[Effect of topical levobunolol on retinal, optic nerve head, and choroidal circulation in normal volunteers]”. Nippon Ganka Gakkai Zasshi 103 (7): 544–50. PMID 10443129.
Leung M, Grunwald J (1997). „Short-term effects of topical levobunolol on the human retinal circulation.”. Eye 11 (3): 371–6. DOI:10.1038/eye.1997.78. PMID 9373479.

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