ZNF74

ZNF74
Identifiers
Aliases	ZNF74, COS52, ZFP520, ZNF520, hZNF7, zinc finger protein 74
External IDs	OMIM: 194548; HomoloGene: 88675; GeneCards: ZNF74; OMA:ZNF74 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	20,408,461 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; gonad; ; ventricular zone; ; buccal mucosa cell; ; stromal cell of endometrium; ; granulocyte; ; prefrontal cortex; ; right hemisphere of cerebellum; ; right frontal lobe; ; anterior cingulate cortex;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; nucleic acid binding; DNA binding; metal ion binding; RNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	intracellular anatomical structure; nucleus; nucleoplasm; actin cytoskeleton;
Biological process	multicellular organism development; transcription, DNA-templated; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	7625
	n/a
	ENSG00000185252
	n/a
	Q16587
	n/a
	NM_001256523; NM_001256524; NM_001256525; NM_003426
	n/a
	NP_001243452; NP_001243453; NP_001243454; NP_003417
	n/a
	Wikidata
View/Edit Human

Zinc finger protein 74 is a protein that in humans is encoded by the ZNF74 gene.^[3]^[4]^[5] Schizophrenia susceptibility has been associated with a mutation in this protein.^[6]

Interactions

ZNF74 has been shown to interact with POLR2A.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185252 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Aubry M, Marineau C, Zhang FR, Zahed L, Figlewicz D, Delattre O, Thomas G, de Jong PJ, Julien JP, Rouleau GA (August 1992). "Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2)". Genomics. 13 (3): 641–8. doi:10.1016/0888-7543(92)90135-F. PMID 1639391.
^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
^ "Entrez Gene: ZNF74 zinc finger protein 74".
^ Takase, K.; T. Ohtsuki; O. Migita; M. Toru; T. Inada; K. Yamakawa-Kobayashi; T. Arinami (1 December 2001). "Association of ZNF74 gene genotypes with age-at-onset of schizophrenia". Schizophrenia Research. 52 (3): 161–165. doi:10.1016/s0920-9964(00)00191-2. PMID 11705709. S2CID 42865851.
^ Grondin B, Côté F, Bazinet M, Vincent M, Aubry M (October 1997). "Direct interaction of the KRAB/Cys2-His2 zinc finger protein ZNF74 with a hyperphosphorylated form of the RNA polymerase II largest subunit". J. Biol. Chem. 272 (44): 27877–85. doi:10.1074/jbc.272.44.27877. PMID 9346935.

External links

ZNF74+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185252 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1639391-3] Aubry M, Marineau C, Zhang FR, Zahed L, Figlewicz D, Delattre O, Thomas G, de Jong PJ, Julien JP, Rouleau GA (August 1992). "Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2)". Genomics. 13 (3): 641–8. doi:10.1016/0888-7543(92)90135-F. PMID 1639391.

[pmid10591208-4] Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.

[entrez-5] "Entrez Gene: ZNF74 zinc finger protein 74".

[schizophrenia-6] Takase, K.; T. Ohtsuki; O. Migita; M. Toru; T. Inada; K. Yamakawa-Kobayashi; T. Arinami (1 December 2001). "Association of ZNF74 gene genotypes with age-at-onset of schizophrenia". Schizophrenia Research. 52 (3): 161–165. doi:10.1016/s0920-9964(00)00191-2. PMID 11705709. S2CID 42865851.

[pmid9346935-7] Grondin B, Côté F, Bazinet M, Vincent M, Aubry M (October 1997). "Direct interaction of the KRAB/Cys2-His2 zinc finger protein ZNF74 with a hyperphosphorylated form of the RNA polymerase II largest subunit". J. Biol. Chem. 272 (44): 27877–85. doi:10.1074/jbc.272.44.27877. PMID 9346935.

[1]

Interactions

References

Further reading

External links