HMGB4

HMGB4
Identifiers
Aliases	HMGB4, dJ1007G16.5, high mobility group box 4
External IDs	OMIM: 617285; MGI: 1916567; HomoloGene: 83321; GeneCards: HMGB4; OMA:HMGB4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	33,864,791 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	128,154,750 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; sperm; ; testicle; ; tail of epididymis; ; right coronary artery; ; caput epididymis; ; ectocervix; ; right uterine tube; ; canal of the cervix;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; muscle tissue; ; central gray substance of midbrain; ; striated muscle tissue; ; pancreas; ; skeletal muscle tissue; ; islet of Langerhans; ; hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; DNA binding; transcription factor binding; DNA binding, bending;
Cellular component	nucleus; chromosome; cytoplasm;
Biological process	activation of innate immune response; DNA recombination; chromatin remodeling; regulation of transcription by RNA polymerase II; regulation of signaling receptor activity; positive regulation of autophagy; developmental process; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of innate immune response; positive regulation of transcription by RNA polymerase II; cell chemotaxis; positive regulation of ERK1 and ERK2 cascade; positive regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
Orthologs
	127540
	69317
	ENSG00000176256
	ENSMUSG00000048686
	Q8WW32
	Q6P8W9
	NM_145205; NM_001352984; NM_001379301
	NM_027036
	NP_660206; NP_001339913; NP_001366230
	NP_081312
	Wikidata
View/Edit Human	View/Edit Mouse

High mobility group protein B4 is a transcription factor that in humans is encoded by the HMGB4 gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000176256 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048686 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: high-mobility group box 4".

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Sogayar MC, Camargo AA, Bettoni F, et al. (2004). "A transcript finishing initiative for closing gaps in the human transcriptome". Genome Res. 14 (7): 1413–23. doi:10.1101/gr.2111304. PMC 442158. PMID 15197164.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000176256 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048686 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: high-mobility group box 4".

[1]

HMGB4

See also

References

Further reading