cyclosporine (Q367700)

reactant

1 reference

Gene Ontology release 2019-11-16

response to cyclosporin A

reactant

1 reference

Gene Ontology release 2019-11-16

cellular response to cyclosporin A

reactant

1 reference

Gene Ontology release 2019-11-16

has use

medication

0 references

chemical structure

Ciclosporin.svg
512 × 431; 16 KB

0 references

image of molecular model or crystal lattice model

Cyclosporin.png
1,588 × 1,800; 609 KB

depicts

ball-and-stick model

0 references

mass

1,201.841 dalton

1 reference

cyclosporin A (English)

18 November 2016

2 references

inferred from InChIKey

cyclo[Abu-Sar-N(Me)Leu-Val-N(Me)Leu-Ala-D-Ala-N(Me)Leu-N(Me)Leu-D-N(Me)Val-D-N(Me)Bmt(E)]

inferred from InChI

2 references

inferred from InChIKey

cyclo[((2S)-2-aminobutyryl)-sarcosyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-N-methyl-(4R)-4-[but-2-enyl]-4-methyl-L-threonyl]

inferred from InChI

1 reference

inferred from InChI

chemical formula

C₆₂H₁₁₁N₁₁O₁₂

1 reference

cyclosporin A (English)

18 November 2016

canonical SMILES

CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C

1 reference

cyclosporin A (English)

18 November 2016

isomeric SMILES

CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C

1 reference

cyclosporin A (English)

European Medicines Agency product number

18 November 2016

active ingredient in

Ikervis

1 reference

EMEA/H/C/002066

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/002066/human_med_001851.jsp

22 March 2017

1 reference

14 February 2018

1 reference

14 February 2018

1 reference

14 February 2018

1 reference

14 February 2018

1 reference

14 February 2018

World Health Organisation international non-proprietary name

ciclosporin (English)

2 references

cyclosporin A (English)

http://identifiers.org/wikipathways/WP2289_r78511

3 October 2016

published in

Recommended INN: List 24

1984

1 reference

10 September 2016

Trichoderma polysporum

1 reference

Cyclosporin A, a Peptide Metabolite from Trichoderma polysporum (Link ex Pers.) Rifai, with a remarkable immunosuppressive activity

Tolypocladium inflatum

1 reference

The genome of tolypocladium inflatum: evolution, organization, and expression of the cyclosporin biosynthetic gene cluster

medical condition treated

focal segmental glomerulosclerosis

1 reference

13 December 2016

1 reference

13 December 2016

1 reference

13 December 2016

1 reference

systemic lupus erythematosus

13 December 2016

1 reference

13 December 2016

2 references

13 December 2016

2 October 2018

erythroblastopenia

1 reference

interstitial lung disease

2 October 2018

1 reference

2 October 2018

myelodysplastic syndrome

1 reference

graft-versus-host disease

2 October 2018

1 reference

2 October 2018

nephrotic syndrome

1 reference

2 October 2018

Behçet's disease

1 reference

2 October 2018

Sjögren's syndrome

1 reference

membranous glomerulonephritis

2 October 2018

1 reference

significant drug interaction

2 October 2018

nabumetone

1 reference

A reference set of clinically relevant adverse drug-drug interactions

naproxen

1 reference

A reference set of clinically relevant adverse drug-drug interactions

celecoxib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

Diclofenac

1 reference

A reference set of clinically relevant adverse drug-drug interactions

piroxicam

1 reference

A reference set of clinically relevant adverse drug-drug interactions

meloxicam

1 reference

A reference set of clinically relevant adverse drug-drug interactions

(RS)-fenoprofen

1 reference

A reference set of clinically relevant adverse drug-drug interactions

(+-)-flurbiprofen

1 reference

A reference set of clinically relevant adverse drug-drug interactions

ibuprofen

1 reference

A reference set of clinically relevant adverse drug-drug interactions

indomethacin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

(RS)-ketoprofen

1 reference

A reference set of clinically relevant adverse drug-drug interactions

(RS)-etodolac

1 reference

A reference set of clinically relevant adverse drug-drug interactions

sulindac

1 reference

A reference set of clinically relevant adverse drug-drug interactions

parecoxib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

aceclofenac

1 reference

A reference set of clinically relevant adverse drug-drug interactions

tenoxicam

1 reference

A reference set of clinically relevant adverse drug-drug interactions

foscarnet

1 reference

A reference set of clinically relevant adverse drug-drug interactions

1 reference

A reference set of clinically relevant adverse drug-drug interactions

amikacin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

streptomycin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

tobramycin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

tacrolimus

1 reference

A reference set of clinically relevant adverse drug-drug interactions

triamterene

1 reference

A reference set of clinically relevant adverse drug-drug interactions

amiloride

1 reference

A reference set of clinically relevant adverse drug-drug interactions

perindopril

1 reference

A reference set of clinically relevant adverse drug-drug interactions

spironolactone

1 reference

A reference set of clinically relevant adverse drug-drug interactions

nabumetone

1 reference

A reference set of clinically relevant adverse drug-drug interactions

naproxen

1 reference

A reference set of clinically relevant adverse drug-drug interactions

celecoxib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

Diclofenac

1 reference

A reference set of clinically relevant adverse drug-drug interactions

piroxicam

1 reference

A reference set of clinically relevant adverse drug-drug interactions

meloxicam

1 reference

A reference set of clinically relevant adverse drug-drug interactions

(RS)-fenoprofen

1 reference

A reference set of clinically relevant adverse drug-drug interactions

(+-)-flurbiprofen

1 reference

A reference set of clinically relevant adverse drug-drug interactions

ibuprofen

1 reference

A reference set of clinically relevant adverse drug-drug interactions

indomethacin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

(RS)-ketoprofen

1 reference

A reference set of clinically relevant adverse drug-drug interactions

(RS)-etodolac

1 reference

A reference set of clinically relevant adverse drug-drug interactions

sulindac

1 reference

A reference set of clinically relevant adverse drug-drug interactions

lisinopril dihydrate

1 reference

A reference set of clinically relevant adverse drug-drug interactions

valsartan

1 reference

A reference set of clinically relevant adverse drug-drug interactions

quinapril

1 reference

A reference set of clinically relevant adverse drug-drug interactions

ramipril

1 reference

A reference set of clinically relevant adverse drug-drug interactions

captopril

1 reference

A reference set of clinically relevant adverse drug-drug interactions

enalapril

1 reference

A reference set of clinically relevant adverse drug-drug interactions

trandolapril

1 reference

A reference set of clinically relevant adverse drug-drug interactions

1 reference

A reference set of clinically relevant adverse drug-drug interactions

trimethoprim

1 reference

A reference set of clinically relevant adverse drug-drug interactions

parecoxib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

aceclofenac

1 reference

A reference set of clinically relevant adverse drug-drug interactions

tenoxicam

1 reference

A reference set of clinically relevant adverse drug-drug interactions

tacrolimus

1 reference

A reference set of clinically relevant adverse drug-drug interactions

trimethoprim

1 reference

A reference set of clinically relevant adverse drug-drug interactions

fenofibrate

1 reference

A reference set of clinically relevant adverse drug-drug interactions

simvastatin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

simvastatin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

atorvastatin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

atorvastatin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

fluvastatin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

fluvastatin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

thrombocytopenia

1 reference

A reference set of clinically relevant adverse drug-drug interactions

leukopenia

1 reference

A reference set of clinically relevant adverse drug-drug interactions

anemia

1 reference

A reference set of clinically relevant adverse drug-drug interactions

mouth ulcer

1 reference

A reference set of clinically relevant adverse drug-drug interactions

verapamil

1 reference

A reference set of clinically relevant adverse drug-drug interactions

verapamil

1 reference

A reference set of clinically relevant adverse drug-drug interactions

verapamil

1 reference

A reference set of clinically relevant adverse drug-drug interactions

diltiazem

1 reference

A reference set of clinically relevant adverse drug-drug interactions

diltiazem

1 reference

A reference set of clinically relevant adverse drug-drug interactions

diltiazem

1 reference

A reference set of clinically relevant adverse drug-drug interactions

danazol

1 reference

A reference set of clinically relevant adverse drug-drug interactions

danazol

1 reference

A reference set of clinically relevant adverse drug-drug interactions

danazol

1 reference

A reference set of clinically relevant adverse drug-drug interactions

1 reference

A reference set of clinically relevant adverse drug-drug interactions

1 reference

A reference set of clinically relevant adverse drug-drug interactions

1 reference

A reference set of clinically relevant adverse drug-drug interactions

saquinavir

1 reference

A reference set of clinically relevant adverse drug-drug interactions

saquinavir

1 reference

A reference set of clinically relevant adverse drug-drug interactions

saquinavir

1 reference

A reference set of clinically relevant adverse drug-drug interactions

erythromycin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

erythromycin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

erythromycin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

clarithromycin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

clarithromycin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

clarithromycin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

fluconazole

1 reference

A reference set of clinically relevant adverse drug-drug interactions

fluconazole

1 reference

A reference set of clinically relevant adverse drug-drug interactions

fluconazole

1 reference

A reference set of clinically relevant adverse drug-drug interactions

Ketoconazole

1 reference

A reference set of clinically relevant adverse drug-drug interactions

Ketoconazole

1 reference

A reference set of clinically relevant adverse drug-drug interactions

Ketoconazole

1 reference

A reference set of clinically relevant adverse drug-drug interactions

cimetidine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

cimetidine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

cimetidine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

leukopenia

1 reference

A reference set of clinically relevant adverse drug-drug interactions

anemia

1 reference

A reference set of clinically relevant adverse drug-drug interactions

thrombocytopenia

1 reference

A reference set of clinically relevant adverse drug-drug interactions

Achor-Smith syndrom

1 reference

A reference set of clinically relevant adverse drug-drug interactions

diarrhea

1 reference

A reference set of clinically relevant adverse drug-drug interactions

ramipril

acute kidney injury

1 reference

A reference set of clinically relevant adverse drug-drug interactions

trandolapril

acute kidney injury

1 reference

A reference set of clinically relevant adverse drug-drug interactions

etoposide

leukopenia

1 reference

A reference set of clinically relevant adverse drug-drug interactions

perindopril

1 reference

A reference set of clinically relevant adverse drug-drug interactions

rosuvastatin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

pravastatin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

pravastatin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

itraconazole

1 reference

A reference set of clinically relevant adverse drug-drug interactions

itraconazole

1 reference

A reference set of clinically relevant adverse drug-drug interactions

itraconazole

1 reference

A reference set of clinically relevant adverse drug-drug interactions

amikacin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

streptomycin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

tobramycin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

physically interacts with

ATP binding cassette subfamily G member 2 (Junior blood group)

1 reference

Formyl peptide receptor 1

17 August 2016

1 reference

Solute carrier organic anion transporter family member 1B1

17 August 2016

1 reference

solute carrier organic anion transporter family member 1B3

17 August 2016

1 reference

peptidylprolyl isomerase A

17 August 2016

1 reference

Solute carrier family 10 member 1

17 August 2016

1 reference

17 August 2016

legal status (medicine)

boxed warning

1 reference

https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802

Australian pregnancy category C

FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links. (English)

pregnancy category

1 reference

imported from Wikimedia project

English Wikipedia

US pregnancy category C

1 reference

imported from Wikimedia project

English Wikipedia

LiverTox likelihood score

LiverTox toxicity likelihood category C

1 reference

8 April 2021

https://www.ncbi.nlm.nih.gov/books/n/livertox/Cyclosporine

last update

17 February 2020

xenobiotic-transporting ATPase inhibitor

1 reference

5 March 2018

disease-modifying antirheumatic drug

1 reference

15 March 2018

1 reference

15 March 2018

1 reference

15 March 2018

1 reference

MeSH descriptor ID

D016572

15 March 2018

immunosuppressive drug

1 reference

MeSH descriptor ID

D016572

15 March 2018

calcineurin inhibitor

1 reference

Food and Drug Administration

15 March 2018

0 references

cycloSPORINE

Cyclosporine

1 reference

https://www.fda.gov/drugs/medication-errors-related-cder-regulated-drug-products/fda-name-differentiation-project

Institute for Safe Medication Practices

2 September 2022

SandIMMUNE

has characteristic

Tall Man lettering

issued by

Sandimmune

1 reference

https://www.ismp.org/recommendations/tall-man-letters-list

Bibliothèque nationale de France ID

2 September 2022

Commons category

Ciclosporin

0 references

Identifiers

120016083

Ciclosporine

1 reference

Nuovo soggettario

https://thes.bncf.firenze.sbn.it/termine.php?id=1331

13 June 2021

1 reference

National Library of Israel

Library of Congress authority ID

sh85035108

Cyclosporine

1 reference

Nuovo soggettario

https://thes.bncf.firenze.sbn.it/termine.php?id=1331

13 June 2021

0 references

InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1

1 reference

inferred from SMILES

2 references

cyclosporin A (English)

18 November 2016

ChEBI release 2020-09-01

CAS Registry Number

59865-13-3

1 reference

Global Substance Registration System

UNII

83HN0GTJ6D

cyclosporine (English)

18 November 2016

0 references

1 reference

Ciclosporin (English)

18 November 2016

2 references

cyclosporin A (English)

18 November 2016

Reaxys registry number

3647785

1 reference

cyclosporin A (English)

3 October 2016

ChEBI ID

4031

mapping relation type

2 references

CYCLOSPORINE (English)

18 November 2016

International Chemical Identifier

1 reference

CYCLOSPORINE (English)

18 November 2016

2 references

inferred from InChIKey

splash10-0ki2-3984222111-839f2c53451fb6b9da59

1 reference

0 references

0 references

1 reference

Hazardous Substances Data Bank

28 October 2019

CYCLOSPORIN A (English)

10 May 2021

2 references

Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard

DSSTOX compound identifier

0 references

0 references

0 references

0 references

611-907-1

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.119.569

27 December 2018

ECHA Substance Infocard ID

(3S,6S,9R,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone (English)

quotation

CAS no.: 59865-13-3 (English)

100.119.569

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.119.569

27 December 2018