fms related receptor tyrosine kinase 4 (Q21118353)

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mammalian protein found in Homo sapiens
  • FLT4
  • VEGF receptor-3
  • vascular endothelial growth factor receptor 3
  • fms-like tyrosine kinase 4
  • tyrosine-protein kinase receptor FLT4
  • primary congenital lymphedema
  • fms related tyrosine kinase 4
  • FLT-4
  • Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4
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    English
    fms related receptor tyrosine kinase 4
    mammalian protein found in Homo sapiens
    • FLT4
    • VEGF receptor-3
    • vascular endothelial growth factor receptor 3
    • fms-like tyrosine kinase 4
    • tyrosine-protein kinase receptor FLT4
    • primary congenital lymphedema
    • fms related tyrosine kinase 4
    • FLT-4
    • Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4

    Statements

    part of
    molecular function
    vascular endothelial growth factor-activated receptor activity
    determination method or standard
    IDA
    IEA
    IMP
    TAS
    6 references
    retrieved
    16 July 2018
    stated in
    Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema
    GOA
    curator
    Proteome Inc.
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916
    determination method or standard
    TAS
    retrieved
    16 July 2018
    stated in
    Autocrine loop between vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 positively regulates tumor-associated lymphangiogenesis in oral squamoid cancer cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P35916
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916
    determination method or standard
    IMP
    retrieved
    16 July 2018
    stated in
    Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3
    GOA
    curator
    UniProt
    UniProt protein ID
    P35916
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916
    determination method or standard
    IMP
    retrieved
    16 July 2018
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916
    determination method or standard
    IEA
    retrieved
    16 July 2018
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916
    determination method or standard
    IEA
    retrieved
    16 July 2018
    stated in
    VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916
    determination method or standard
    IDA
    protein binding
    determination method or standard
    IPI
    5 references
    retrieved
    8 April 2019
    stated in
    Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation
    GOA
    curator
    UniProt
    UniProt protein ID
    P35916
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
    determination method or standard
    IPI
    vascular endothelial growth factor-activated receptor activity
    determination method or standard
    IBA
    IDA
    IEA
    IMP
    TAS
    7 references
    retrieved
    8 April 2019
    stated in
    Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema
    GOA
    curator
    Proteome Inc.
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3
    GOA
    curator
    UniProt
    UniProt protein ID
    P35916
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Autocrine loop between vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 positively regulates tumor-associated lymphangiogenesis in oral squamoid cancer cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P35916
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
    determination method or standard
    IBA
    cell component
    biological process
    vascular endothelial growth factor receptor signaling pathway
    determination method or standard
    IDA
    IGI
    TAS
    IMP
    IEA
    6 references
    retrieved
    10 September 2018
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916
    determination method or standard
    TAS
    retrieved
    10 September 2018
    stated in
    Autocrine loop between vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 positively regulates tumor-associated lymphangiogenesis in oral squamoid cancer cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P35916
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916
    determination method or standard
    IMP
    retrieved
    10 September 2018
    stated in
    Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3
    GOA
    curator
    UniProt
    UniProt protein ID
    P35916
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916
    determination method or standard
    IMP
    retrieved
    10 September 2018
    stated in
    Multiple forms of mouse vascular endothelial growth factor-D are generated by RNA splicing and proteolysis
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916
    determination method or standard
    IGI
    retrieved
    10 September 2018
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916
    determination method or standard
    IEA
    retrieved
    10 September 2018
    stated in
    VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916
    determination method or standard
    IDA
    positive regulation of cell population proliferation
    determination method or standard
    IBA
    IEA
    IGI
    IMP
    5 references
    retrieved
    8 April 2019
    stated in
    Mutation at tyrosine residue 1337 abrogates ligand-dependent transforming capacity of the FLT4 receptor
    GOA
    curator
    UniProt
    UniProt protein ID
    P35916
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Autocrine loop between vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 positively regulates tumor-associated lymphangiogenesis in oral squamoid cancer cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P35916
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Multiple forms of mouse vascular endothelial growth factor-D are generated by RNA splicing and proteolysis
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
    determination method or standard
    IBA
    vascular endothelial growth factor receptor signaling pathway
    determination method or standard
    IBA
    IDA
    IEA
    IGI
    IMP
    TAS
    7 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3
    GOA
    curator
    UniProt
    UniProt protein ID
    P35916
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Autocrine loop between vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 positively regulates tumor-associated lymphangiogenesis in oral squamoid cancer cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P35916
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Multiple forms of mouse vascular endothelial growth factor-D are generated by RNA splicing and proteolysis
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
    determination method or standard
    IBA
    physically interacts with

    Identifiers

    MeSH descriptor ID
    D040321
    subject named as
    Vascular Endothelial Growth Factor Receptor-3
    0 references
     
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