Indapamid

Indapamid
IUPAC ime
	4-hloro-N-(2-metil-2,3-dihidro-1Hindol-1-il)-3-sulfamoilbenzamid
Klinički podaci
Prodajno ime	Apo-Indapamide, Arifon, Bajaten, Cormil
Drugs.com	Monografija
Način primene	Oralno
Farmakokinetički podaci
Poluvreme eliminacije	14 sati
Identifikatori
CAS broj	26807-65-8
ATC kod	C03BA11 (WHO)
PubChem	CID 3702
DrugBank	DB00808
ChemSpider	3574
Hemijski podaci
Formula	C16H16ClN3O3S
Molarna masa	365.835
	SMILES CC1CC2=CC=CC=C2N1NC(=O)C1=CC(=C(Cl)C=C1)S(N)(=O)=O; ;
	InChI InChI=1S/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23) ; Key:NDDAHWYSQHTHNT-UHFFFAOYSA-N ;
Fizički podaci
Tačka topljenja	161 °C (322 °F)

Indapamid je benzamid-sulfonamid-indol. On je tiazidu sličan diureti, mada ne sadrži tiazidni prsten. Koristi se za tretiranje hipertenzije, kao i dekompenzovane srčane insuficijencije. On je u prodaji pod imenom Lozol.^[1]^[2]^[3]^[4]

Reference

^ Lozol
^ Dong DL, Wang QH, Yue P, Jiao JD, Gu RM, Yang BF: Indapamide induces apoptosis of GH3 pituitary cells independently of its inhibition of voltage-dependent K+ currents. Eur J Pharmacol. 2006 Apr 24;536(1-2):78-84. Epub 2006 Mar 2. PMID 16556441
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMID 21059682.
^ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res. 36 (Database issue): D901—6. PMID 18048412.

Spoljašnje veze

Indapamide

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Lozol

[2] Dong DL, Wang QH, Yue P, Jiao JD, Gu RM, Yang BF: Indapamide induces apoptosis of GH3 pituitary cells independently of its inhibition of voltage-dependent K+ currents. Eur J Pharmacol. 2006 Apr 24;536(1-2):78-84. Epub 2006 Mar 2. PMID 16556441

[3] Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMID 21059682.

[4] Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res. 36 (Database issue): D901—6. PMID 18048412.

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