Betahistin

Betahistin
(IUPAC) ime
	N-metil-2-(piridin-2-il)etanamin
Klinički podaci
AHFS/Drugs.com	Internacionalno ime leka
Identifikatori
CAS broj	5638-76-6
ATC kod	N07CA01
PubChem	2366
DrugBank	DB06698
ChemSpider	2276
UNII	X32KK4201D
KEGG	D07522
ChEBI	CHEBI:35677
ChEMBL	CHEMBL24441
Hemijski podaci
Formula	C8H12N2
Mol. masa	136,194 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C8H12N2/c1-9-7-5-8-4-2-3-6-10-8/h2-4,6,9H,5,7H2,1H3 ; Key: UUQMNUMQCIQDMZ-UHFFFAOYSA-N
Farmakokinetički podaci
Vezivanje za proteine plazme	veoma nizank
Metabolizam	Do 2-(2-aminoetil)piridina i 2-piridilsirćetne kiselina
Poluvreme eliminacije	3–4 sata
Izlučivanje	Renalno
Farmakoinformacioni podaci
Trudnoća	?
Pravni status
Način primene	Oralno

Betahistin hidrohlorid (Serc, Hiserk, Betaserc) je lek protiv vrtoglavice. On je prvo registrovan u Evropi 1970 za tretman Menijerove bolesti. On se obično propisuje pacijentima sa poremećajem balansa ili za olakšavanje simptoma vrtoglavice vezanih za Menijerovu bolest.

Hemija

Betahistin je hemijski 2-[2-(metilamino)etil]piridin, i formuliše se kao dihidrohloridna so. Njegova struktura je blisko slična sa fenetilaminom i histaminom.

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ (fr) „Betahistine Dichlorhydrate”. BIAM. 30. 6. 1999.. Retrieved on November 7, 2008.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[BIAM-6] (fr) „Betahistine Dichlorhydrate”. BIAM. 30. 6. 1999.. Retrieved on November 7, 2008.

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