HLA-A25

HLA-A25
(MHC Class I, A cell surface antigen)
HLA-A25
About
Protein	transmembrane receptor/ligand
Structure	αβ heterodimer
Subunits	HLA-A*2501, β2-microglobulin
Older names	A10
Subtypes
Subtype allele Available structures A25 *2501 {{{cNick2}}} *25{{{cAllele2}}} {{{cNick3}}} *25{{{cAllele3}}} {{{cNick4}}} *25{{{cAllele4}}}
Alleles link-out to IMGT/HLA database at EBI

HLA-A25 (A25) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α²⁵ subset of HLA-A α-chains. For A25, the alpha "A" chain are encoded by the HLA-A*25 allele group and the β-chain are encoded by B2M locus.^[1] This group currently is dominated by A*2501. A25 and A*25 are almost synonymous in meaning. A25 is a split antigen of the broad antigen serotype A10. A25 is a sister serotype of A26, A34, A43, and A66.

A25 is more common in SW Asia to NW Europe. A25 is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.^[2].

A25 reasonably good serotyping with no overt false recognition..

A*2501 distribution is primarily located in Western Eurasia. Frequency tends to be highest in the populations that underwent later neolithization suggesting A*2501 spread in Europe. The high frequency in Saudi Arabia is suggestive of a source.