AM大麻素列表

美国麻薩諸塞州东北大学亚历山德罗斯·马克里扬尼斯（Alexandros Makriyannis）的研究小组合成了许多大麻素，统称为AM大麻素，其中一些是：

大麻素及其K_i值(K_i是化合物对大麻素1型受体（CB₁）或大麻素2型受体（CB₂）的结合亲和力)
名称	CAS号	类别	分子式	K_i/nM (CB₁)	K_i/nM (CB₂)	选择性	ref
AM-087	152674-96-9	二苯并吡喃	C₂₃H₃₃BrO₂	0.43
AM-251	183232-66-8	吡唑衍生物	C₂₂H₂₁Cl₂IN₄O	7.5			^[1]
AM-279
AM-281
AM-356	157182-49-5		C₂₃H₃₉NO₂	17.9	868		^[2]
AM-374
AM-381
AM-404	183718-77-6		C₂₆H₃₇NO₂
AM-411	212835-02-4	二苯并吡喃	C₂₆H₃₄O₂	6.8	52.0
AM-630	164178-33-0	苯甲酰基吲哚	C₂₃H₂₅IN₂O₃		32.1	CB₂(165×)
AM-661
AM-678 （JWH-018）	209414-07-3	萘甲酰基吲哚	C₂₄H₂₃NO	9.00±5.00	2.94±2.65	CB₂
AM-679	335160-91-3	苯甲酰基吲哚	C₂₀H₂₀INO	13.5	49.5	CB₁
AM-694	335161-03-0	苯甲酰基吲哚	C₂₀H₁₉FINO	0.08	1.44	CB₁(18×)	^[3]
AM-735
AM-855	249888-50-4		C₂₆H₃₈O₂	22.3	58.6	CB₁
AM-881
AM-883
AM-905	181139-62-8		C₂₃H₃₄O₃	1.2	5.3	CB₁
AM-906	180989-26-8		C₂₃H₃₄O₃	0.8	9.5	CB₁
AM-919	164228-46-0		C₂₇H₄₄O₄	2.2	3.4	CB₁
AM-926
AM-938	303113-08-8		C₂₇H₄₀O₄	1.2	0.3	CB₂(4×)
AM-1116
AM-1172
AM-1220	134959-64-1	萘甲酰基吲哚	C₂₆H₂₆N₂O	3.88	73.4	CB₁ (19×)	^[4]^[5]
AM-1221	335160-53-7	萘甲酰基吲哚	C 27H 27N 3O 3	52.3	0.28	CB₂ (187×)
AM-1235
AM-1241	444912-48-5		C 22H 22IN 3O 3
AM-1248	335160-66-2		C 26H 34N 2O
AM-1710	335371-36-3		C 23H 28O 4
AM-1714	335371-37-4		C 22H 26O 4
AM-1902
AM-2201	335161-24-5		C 24H 22FNO
AM-2212
AM-2213
AM-2232	335161-19-8		C 24H 20N 2O
AM-2233	444912-75-8		C 22H 23IN 2O
AM-2389	1256842-49-5		C 25H 38O 3
AM-3102
AM-4030	587023-54-9		C₂₇H₄₂O₄	0.7	8.6	CB₁
AM-4054
AM-4056 （HU-243）	140835-18-3		C 25H 40O 3
AM-4113
AM-6545	1245626-05-4		C 26H 23Cl 2N 5O 3S
AM-7438	1577225-74-1		C₂₄H₃₁NO₄
AM-11245	2762979-76-8		C₂₆H₃₉NO₃

AMG系列大麻素
名称	类别	分子式	CAS号
AMG-1	二苯并吡喃	C₂₃H₃₀O₂	205746-46-9
AMG-3	二苯并吡喃	C₂₅H₃₆O₂S₂	179044-94-1
AMG-36	二苯并吡喃	C₂₇H₄₀O₂	579444-43-2
AMG-41	二苯并吡喃	C₂₅H₃₆O₂	499237-35-3

参见

参考文献

^ Lan, Ruoxi; Lu, Qian; Fan, Pusheng; Gatley, John; Volkow, Nora D.; Fernando, Susanthi R.; Pertwee, Roger; Makriyannis, Alexandros. Design and synthesis of the CB1 selective cannabinoid antagonist AM281: A potential human SPECT ligand. AAPS PharmSci. 1999, 1 (2): 39–45. PMC 2761119 . PMID 11741201. doi:10.1208/ps010204.
^ Selwood, D. The Cannabinoid Receptors. Edited by Patricia H. Reggio. ChemMedChem. 2009, 4: 1949. doi:10.1002/cmdc.200900286.
^ Template:Ref patent2
^ D'ambra, T. C-Attached aminoalkylindoles: potent cannabinoid mimetics. Bioorganic & Medicinal Chemistry Letters. 1996, 6: 17–22. doi:10.1016/0960-894X(95)00560-G.
^ Willis, P. G.; Pavlova, O. A.; Chefer, S. I.; Vaupel, D. B.; Mukhin, A. G.; Horti, A. G. Synthesis and Structure−Activity Relationship of a Novel Series of Aminoalkylindoles with Potential for Imaging the Neuronal Cannabinoid Receptor by Positron Emission Tomography. Journal of Medicinal Chemistry. 2005, 48 (18): 5813–22. PMID 16134948. doi:10.1021/jm0502743.

[SPECTligand-1] Lan, Ruoxi; Lu, Qian; Fan, Pusheng; Gatley, John; Volkow, Nora D.; Fernando, Susanthi R.; Pertwee, Roger; Makriyannis, Alexandros. Design and synthesis of the CB1 selective cannabinoid antagonist AM281: A potential human SPECT ligand. AAPS PharmSci. 1999, 1 (2): 39–45. PMC 2761119 . PMID 11741201. doi:10.1208/ps010204.

[Receptors-2] Selwood, D. The Cannabinoid Receptors. Edited by Patricia H. Reggio. ChemMedChem. 2009, 4: 1949. doi:10.1002/cmdc.200900286.

[WO_2001_28557_A1-3] Template:Ref patent2

[4] D'ambra, T. C-Attached aminoalkylindoles: potent cannabinoid mimetics. Bioorganic & Medicinal Chemistry Letters. 1996, 6: 17–22. doi:10.1016/0960-894X(95)00560-G.

[5] Willis, P. G.; Pavlova, O. A.; Chefer, S. I.; Vaupel, D. B.; Mukhin, A. G.; Horti, A. G. Synthesis and Structure−Activity Relationship of a Novel Series of Aminoalkylindoles with Potential for Imaging the Neuronal Cannabinoid Receptor by Positron Emission Tomography. Journal of Medicinal Chemistry. 2005, 48 (18): 5813–22. PMID 16134948. doi:10.1021/jm0502743.

[1]