Janus kinase 3 (Q6155969)

tyrosine-protein kinase, non-receptor Jak3

1 reference

SH2 domain superfamily

1 reference

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

SH2 domain, protein family

1 reference

Band 4.1 domain, protein family

1 reference

FERM domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

image

Protein JAK3 PDB 1yvj.png
961 × 702; 392 KB

0 references

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

1 reference

8 April 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

1 reference

8 April 2019

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

1 reference

8 April 2019

non-membrane spanning protein tyrosine kinase activity

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

1 reference

8 April 2019

protein binding

protein tyrosine kinase activity

IPI

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

5 references

8 April 2019

8 April 2019

Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

8 April 2019

protein phosphatase binding

IPI

1 reference

8 April 2019

The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

signaling receptor binding

IPI

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52333&geneProductId=UniProtKB:P52333

1 reference

21 June 2018

cell component

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

1 reference

8 April 2019

extrinsic component of cytoplasmic side of plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52333&geneProductId=UniProtKB:P52333

1 reference

21 June 2018

cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

1 reference

8 April 2019

endomembrane system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

1 reference

8 April 2019

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

1 reference

8 April 2019

endosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

1 reference

8 April 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

1 reference

8 April 2019

negative regulation of FasL production

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

negative regulation of interleukin-10 production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

growth hormone receptor signaling pathway via JAK-STAT

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

response to interleukin-15

1 reference

8 April 2019

Regulation of JAK3 expression and activation in human B cells and B cell malignancies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

adaptive immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

1 reference

8 April 2019

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

1 reference

8 April 2019

interleukin-4-mediated signaling pathway

IDA

1 reference

8 April 2019

JAK3 associates with the human interleukin 4 receptor and is tyrosine phosphorylated following receptor triggering

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

IDA

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

1 reference

8 April 2019

response to interleukin-2

1 reference

8 April 2019

Distinct effects of Jak3 signaling on alphabeta and gammadelta thymocyte development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

negative regulation of thymocyte apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

MAPK cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

1 reference

8 April 2019

tyrosine phosphorylation of STAT protein

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52333&geneProductId=UniProtKB:P52333

negative regulation of T-helper 1 cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

negative regulation of dendritic cell cytokine production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

regulation of T cell apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

positive regulation of T cell proliferation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

peptidyl-tyrosine autophosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52333&geneProductId=UniProtKB:P52333

1 reference

21 June 2018

peptidyl-tyrosine phosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

negative regulation of T cell activation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

enzyme linked receptor protein signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

cell migration

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52333&geneProductId=UniProtKB:P52333

1 reference

21 June 2018

response to interleukin-9

1 reference

8 April 2019

Regulation of JAK3 expression and activation in human B cells and B cell malignancies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

negative regulation of interleukin-12 production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52333&geneProductId=UniProtKB:P52333

1 reference

21 June 2018

erythrocyte differentiation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

regulation of apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52333&geneProductId=UniProtKB:P52333

1 reference

21 June 2018

interleukin-7-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

1 reference

8 April 2019

interleukin-15-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

1 reference

8 April 2019

interleukin-9-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

1 reference

8 April 2019

cytokine-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52333&geneProductId=UniProtKB:P52333

1 reference

21 June 2018

interleukin-2-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

1 reference

8 April 2019

interleukin-21-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

1 reference

8 April 2019

regulation of receptor signaling pathway via JAK-STAT

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

T cell homeostasis

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

innate immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52333

1 reference

8 April 2019

physically interacts with

1 reference

7791

17 August 2016

1 reference

7793

17 August 2016

1 reference

5688

17 August 2016

1 reference

5677

English

object of statement has role

17 August 2016

upadacitinib

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3622821

decernotinib

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3039513

peficitinib

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3137308

has part(s)

tyrosine-protein kinase, active site

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

SH2 domain

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

Band 4.1 domain

1 reference

FERM domain

1 reference

D08.811.913.696.620.682.725.124.300

Identifiers

MeSH descriptor ID

D053616

subject named as

Janus Kinase 3

0 references

MeSH tree code

0 references

D12.776.476.568.124.300

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

0 references

McClintock and Strong Biblical Cyclopedia ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference

UMLS 2023