fibroblast growth factor receptor 1 (Q5446453)

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mammalian protein found in Homo sapiens
  • FGFR1
  • heparin-binding growth factor receptor
  • FGFR1/PLAG1 fusion
  • FMS-like tyrosine kinase 2
  • hydroxyaryl-protein kinase
  • fibroblast growth factor receptor 1
  • BFGFR
  • FLT-2
  • basic fibroblast growth factor receptor 1
  • N-sam
  • fms-related tyrosine kinase 2
  • proto-oncogene c-Fgr
  • bFGF-R-1
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    English
    fibroblast growth factor receptor 1
    mammalian protein found in Homo sapiens
    • FGFR1
    • heparin-binding growth factor receptor
    • FGFR1/PLAG1 fusion
    • FMS-like tyrosine kinase 2
    • hydroxyaryl-protein kinase
    • fibroblast growth factor receptor 1
    • BFGFR
    • FLT-2
    • basic fibroblast growth factor receptor 1
    • N-sam
    • fms-related tyrosine kinase 2
    • proto-oncogene c-Fgr
    • bFGF-R-1

    Statements

    part of
    molecular function
    protein binding
    determination method or standard
    IPI
    23 references
    retrieved
    8 April 2019
    stated in
    Novel Recognition Motif on Fibroblast Growth Factor Receptor Mediates Direct Association and Activation of SNT Adapter Proteins
    GOA
    curator
    UniProt
    UniProt protein ID
    P11362
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Association of CD24 with the kinase c-fgr in a small cell lung cancer cell line and with the kinase lyn in an erythroleukemia cell line
    GOA
    curator
    UniProt
    UniProt protein ID
    P11362
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural basis for FGF receptor dimerization and activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Fibroblast growth factor receptor 1- 5-hydroxytryptamine 1A heteroreceptor complexes and their enhancement of hippocampal plasticity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    FGF-1 and FGF-2 modulate the E-cadherin/catenin system in pancreatic adenocarcinoma cell lines
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Myeloproliferative disorder FOP-FGFR1 fusion kinase recruits phosphoinositide-3 kinase and phospholipase Cgamma at the centrosome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural and Functional Integration of the PLCγ Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The F-BAR protein NOSTRIN participates in FGF signal transduction and vascular development.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Grb14 inhibits FGF receptor signaling through the regulation of PLCγ recruitment and activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Control of fibroblast growth factor receptor kinase signal transduction by heterodimerization of combinatorial splice variants
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IPI
    fibroblast growth factor-activated receptor activity
    determination method or standard
    IEA
    TAS
    IDA
    6 references
    retrieved
    27 February 2018
    stated in
    Diverse forms of a receptor for acidic and basic fibroblast growth factors
    GOA
    curator
    UniProt
    UniProt protein ID
    P11362
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P11362&geneProductId=UniProtKB:P11362
    determination method or standard
    TAS
    retrieved
    27 February 2018
    stated in
    A novel type I fibroblast growth factor receptor activates mitogenic signaling in the absence of detectable tyrosine phosphorylation of FRS2
    GOA
    curator
    Proteome Inc.
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P11362&geneProductId=UniProtKB:P11362
    determination method or standard
    TAS
    retrieved
    27 February 2018
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P11362&geneProductId=UniProtKB:P11362
    determination method or standard
    IEA
    retrieved
    27 February 2018
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P11362&geneProductId=UniProtKB:P11362
    determination method or standard
    IEA
    retrieved
    27 February 2018
    stated in
    Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis
    GOA
    curator
    UniProt
    UniProt protein ID
    P11362
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P11362&geneProductId=UniProtKB:P11362
    determination method or standard
    IDA
    retrieved
    27 February 2018
    stated in
    Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P11362
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P11362&geneProductId=UniProtKB:P11362
    determination method or standard
    IDA
    fibroblast growth factor-activated receptor activity
    determination method or standard
    IBA
    IDA
    IEA
    TAS
    7 references
    retrieved
    8 April 2019
    stated in
    Diverse forms of a receptor for acidic and basic fibroblast growth factors
    GOA
    curator
    UniProt
    UniProt protein ID
    P11362
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    A novel type I fibroblast growth factor receptor activates mitogenic signaling in the absence of detectable tyrosine phosphorylation of FRS2
    GOA
    curator
    Proteome Inc.
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis
    GOA
    curator
    UniProt
    UniProt protein ID
    P11362
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P11362
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IBA
    cell component
    biological process
    fibroblast growth factor receptor signaling pathway
    determination method or standard
    IEA
    TAS
    IPI
    IDA
    IGI
    8 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    A novel type I fibroblast growth factor receptor activates mitogenic signaling in the absence of detectable tyrosine phosphorylation of FRS2
    GOA
    curator
    Proteome Inc.
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Receptor specificity of the fibroblast growth factor family
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Receptor specificity of the fibroblast growth factor family
    GOA
    curator
    UniProt
    UniProt protein ID
    P11362
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IDA
    positive regulation of cell population proliferation
    determination method or standard
    IBA
    IDA
    IEA
    IGI
    IMP
    6 references
    retrieved
    8 April 2019
    stated in
    Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction
    GOA
    curator
    UniProt
    UniProt protein ID
    P11362
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Receptor specificity of the fibroblast growth factor family
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Receptor specificity of the fibroblast growth factor family
    GOA
    curator
    UniProt
    UniProt protein ID
    P11362
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
    determination method or standard
    IBA
    Gene Atlas image
    PBB GE FGFR1 211535 s at fs.png
    732 × 530; 12 KB
    0 references
    has part(s)

    Identifiers

    MeSH descriptor ID
    D051496
    subject named as
    Receptor, Fibroblast Growth Factor, Type 1
    0 references
    RefSeq protein ID
    Ensembl protein ID
    PDB structure ID
     
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