E2F transcription factor 1 (Q5322375)

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mammalian protein found in Homo sapiens
  • retinoblastoma-binding protein 3
  • RBBP-3
  • transcription factor E2F1
  • RBAP-1
  • PRB-binding protein E2F-1
  • PBR3
  • retinoblastoma-associated protein 1
  • E2F1
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    English
    E2F transcription factor 1
    mammalian protein found in Homo sapiens
    • retinoblastoma-binding protein 3
    • RBBP-3
    • transcription factor E2F1
    • RBAP-1
    • PRB-binding protein E2F-1
    • PBR3
    • retinoblastoma-associated protein 1
    • E2F1

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    39 references
    retrieved
    8 April 2019
    stated in
    Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription
    GOA
    curator
    UniProt
    UniProt protein ID
    Q01094
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B
    GOA
    curator
    UniProt
    UniProt protein ID
    Q01094
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release
    GOA
    curator
    UniProt
    UniProt protein ID
    Q01094
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mixed lineage leukemia 5 (MLL5) protein regulates cell cycle progression and E2F1-responsive gene expression via association with host cell factor-1 (HCF-1)
    GOA
    curator
    UniProt
    UniProt protein ID
    Q01094
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Regulation of E2F1 function by the nuclear corepressor KAP1
    GOA
    curator
    UniProt
    UniProt protein ID
    Q01094
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression
    GOA
    curator
    UniProt
    UniProt protein ID
    Q01094
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    E2F transcriptional activation requires TRRAP and GCN5 cofactors
    GOA
    curator
    UniProt
    UniProt protein ID
    Q01094
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis
    GOA
    curator
    UniProt
    UniProt protein ID
    Q01094
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    DDB, a Putative DNA Repair Protein, Can Function as a Transcriptional Partner of E2F1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Regulation of TopBP1 oligomerization by Akt/PKB for cell survival
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A comprehensive resource of interacting protein regions for refining human transcription factor networks
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structure of the human Papillomavirus E7 oncoprotein and its mechanism for inactivation of the retinoblastoma tumor suppressor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Proapoptotic function of the retinoblastoma tumor suppressor protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Regulation of DNA methyltransferase 1 transcription in BRCA1-mutated breast cancer: a novel crosstalk between E2F1 motif hypermethylation and loss of histone H3 lysine 9 acetylation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    DNA-damage-responsive acetylation of pRb regulates binding to E2F-1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A High-Density Map for Navigating the Human Polycomb Complexome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Multimolecular complex of Par-4 and E2F1 binding to Smac promoter contributes to glutamate-induced apoptosis in human- bone mesenchymal stem cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    TRIM16 acts as a tumour suppressor by inhibitory effects on cytoplasmic vimentin and nuclear E2F1 in neuroblastoma cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    GCN5 and E2F1 stimulate nucleotide excision repair by promoting H3K9 acetylation at sites of damage.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Arginine methylation controls growth regulation by E2F-1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Retinoblastoma protein represses transcription by recruiting a histone deacetylase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Retinoblastoma protein recruits histone deacetylase to repress transcription
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    hSirT1-dependent regulation of the PCAF-E2F1-p73 apoptotic pathway in response to DNA damage
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    E2F-1 has dual roles depending on the cell cycle
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IPI
    DNA-binding transcription factor activity, RNA polymerase II-specific
    determination method or standard
    IBA
    IMP
    ISA
    ISM
    NAS
    5 references
    retrieved
    8 April 2019
    stated in
    A census of human transcription factors: function, expression and evolution
    GOA
    curator
    Norwegian University of Science and Technology, Systems Biology team
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    NAS
    retrieved
    8 April 2019
    stated in
    A census of human transcription factors: function, expression and evolution
    GOA
    curator
    Norwegian University of Science and Technology, Systems Biology team
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    ISM
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Norwegian University of Science and Technology, Systems Biology team
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    ISA
    retrieved
    8 April 2019
    stated in
    Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B
    GOA
    curator
    UniProt
    UniProt protein ID
    Q01094
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094
    determination method or standard
    IBA
    cell component
    biological process
    Gene Atlas image
    PBB GE E2F1 2028 s at fs.png
    732 × 530; 12 KB
    0 references

    Identifiers

    MeSH descriptor ID
    D050687
    subject named as
    E2F1 Transcription Factor
    0 references
     
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