Increased heterologous production of the antitumoral polyketide mithramycin A by engineered Streptomyces lividans TK24 strains (Q48192976)

9 February 2018

http://europepmc.org/abstract/MED/29196786

title

Increased heterologous production of the antitumoral polyketide mithramycin A by engineered Streptomyces lividans TK24 strains (English)

1 reference

9 February 2018

http://europepmc.org/abstract/MED/29196786

main subject

Streptomyces argillaceus

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inferred from

reverse claim

Streptomyces lividans

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1 reference

1 reference

Streptomyces anthocyanicus

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29196786%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Renata Novakova

1 reference

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11 June 2020

Luz Elena Núñez

1 reference

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11 June 2020

Dagmar Homerova

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11 June 2020

Renata Knirschova

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11 June 2020

Lubomira Feckova

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11 June 2020

Bronislava Rezuchova

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11 June 2020

Beatrica Sevcikova

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11 June 2020

Nuria Menéndez

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11 June 2020

Francisco Morís

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11 June 2020

Jan Kormanec

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11 June 2020

language of work or name

English

0 references

publication date

1 December 2017

1 reference

9 February 2018

http://europepmc.org/abstract/MED/29196786

published in

Applied Microbiology and Biotechnology

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11 June 2020

volume

102

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11 June 2020

issue

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11 June 2020

page(s)

857-869

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Protein secretion biotechnology in Gram-positive bacteria with special emphasis on Streptomyces lividans

11 June 2020

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Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity

21 January 2018

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The structure of aureolic acid (mithramycin).

21 January 2018

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Investigations into viomycin biosynthesis by using heterologous production in Streptomyces lividans

21 January 2018

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Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)

21 January 2018

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Cloning and Heterologous Expression of the Grecocycline Biosynthetic Gene Cluster

21 January 2018

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Modulation of specificity protein 1 by mithramycin A as a novel therapeutic strategy for cervical cancer

21 January 2018

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21 January 2018

Bacterial tyrosinases

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redD and actII-ORF4, pathway-specific regulatory genes for antibiotic production in Streptomyces coelicolor A3(2), are transcribed in vitro by an RNA polymerase holoenzyme containing sigma hrdD.

21 January 2018

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The chromomycin CmmA acetyltransferase: a membrane-bound enzyme as a tool for increasing structural diversity of the antitumour mithramycin

21 January 2018

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PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin

21 January 2018

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Utilization of a reporter system based on the blue pigment indigoidine biosynthetic gene bpsA for detection of promoter activity and deletion of genes in Streptomyces

21 January 2018

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Metabolic and evolutionary insights into the closely-related species Streptomyces coelicolor and Streptomyces lividans deduced from high-resolution comparative genomic hybridization.

21 January 2018

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Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin

21 January 2018

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The aureolic acid family of antitumor compounds: structure, mode of action, biosynthesis, and novel derivatives

21 January 2018

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Modulation of the activity of Sp transcription factors by mithramycin analogues as a new strategy for treatment of metastatic prostate cancer

21 January 2018

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Expanding the Chemical Diversity of the Antitumoral Compound Mithramycin by Combinatorial Biosynthesis and Biocatalysis: The Quest for Mithralogs with Improved Therapeutic Window

21 January 2018

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Iterative marker excision system

21 January 2018

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A Novel Mithramycin Analogue with High Antitumor Activity and Less Toxicity Generated by Combinatorial Biosynthesis

21 January 2018

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Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.

21 January 2018

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Identification of Mithramycin Analogues with Improved Targeting of the EWS-FLI1 Transcription Factor

21 January 2018

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Antitumoral activity of the mithralog EC-8042 in triple negative breast cancer linked to cell cycle arrest in G2

21 January 2018

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Heterologous production of daptomycin in Streptomyces lividans.

21 January 2018

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Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin

21 January 2018

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Inhibition of Sp1-dependent transcription and antitumor activity of the new aureolic acid analogues mithramycin SDK and SK in human ovarian cancer xenografts

21 January 2018

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Mithramycin SK, A Novel Antitumor Drug with Improved Therapeutic Index, Mithramycin SA, and Demycarosyl-mithramycin SK: Three New Products Generated in the Mithramycin Producer Streptomyces argillaceus through Combinatorial Biosynthesis

21 January 2018

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A two-plasmid system for identification of promoters recognized by RNA polymerase containing extracytoplasmic stress response sigma(E) in Escherichia coli.

21 January 2018

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Complete genome sequence of Streptomyces lividans TK24.

21 January 2018

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Efficient Bioconversion of Echinocandin B to Its Nucleus by Overexpression of Deacylase Genes in Different Host Strains

21 January 2018

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Identification of genetic variations associated with epsilon-poly-lysine biosynthesis in Streptomyces albulus ZPM by genome sequencing

21 January 2018

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Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A.

21 January 2018

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Engineering precursor metabolite pools for increasing production of antitumor mithramycins in Streptomyces argillaceus

21 January 2018

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New Aminocoumarins from the Rare Actinomycete Catenulispora acidiphila DSM 44928: Identification, Structure Elucidation, and Heterologous Production

21 January 2018

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9 March 2024

https://opencitations.net/index/api/v1/citations/10.1002/CBIC.201300712

Identification of Two Genes from Streptomyces argillaceus Encoding Glycosyltransferases Involved in Transfer of a Disaccharide during Biosynthesis of the Antitumor Drug Mithramycin

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12 April 2024

https://opencitations.net/index/api/v1/citations/10.1128/JB.180.18.4929-4937.1998

Identifiers

DOI

10.1007/S00253-017-8642-5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29196786%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29196786%20AND%20SRC:MED&resulttype=core&format=json