Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer (Q34387974)

1 August 2017

title

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer (English)

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1 August 2017

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Matthew Kraman

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Christine Feig

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Edward W Roberts

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David A Tuveson

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1 August 2017

James O Jones

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1 August 2017

Richard J B Wells

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1 August 2017

Andrew Deonarine

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1 August 2017

Derek S Chan

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Claire M Connell

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1 August 2017

Qi Zhao

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Otavia L Caballero

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1 August 2017

Tobias Janowitz

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Duncan I Jodrell

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Douglas T Fearon

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1 August 2017

language of work or name

English

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publication date

25 November 2013

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Proceedings of the National Academy of Sciences of the United States of America

1 August 2017

published in

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1 August 2017

volume

110

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1 August 2017

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1 August 2017

page(s)

20212-20217

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Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma

1 August 2017

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Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia.

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Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

6 July 2018

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HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

6 July 2018

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Endogenous T Cell Responses to Antigens Expressed in Lung Adenocarcinomas Delay Malignant Tumor Progression

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

6 July 2018

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Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

6 July 2018

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Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer

6 July 2018

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Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion

6 July 2018

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Active movement of T cells away from a chemokine

6 July 2018

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Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor Fusin/CXCR-4

6 July 2018

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Enhancement of antitumor immunity by CTLA-4 blockade

6 July 2018

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Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers

6 July 2018

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Phase 2 Trial of Single Agent Ipilimumab (Anti-CTLA-4) for Locally Advanced or Metastatic Pancreatic Adenocarcinoma

6 July 2018

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Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner.

27 October 2018

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Prognostic significance of CXCL12 expression in patients with colorectal carcinoma

27 October 2018

1 reference

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Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4.

27 October 2018

1 reference

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High levels of expression of human stromal cell-derived factor-1 are associated with worse prognosis in patients with stage II pancreatic ductal adenocarcinoma

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24277834

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24277834

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1320318110

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1 August 2017

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1 August 2017

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