programmed cell death 1 (Q21208025)

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mammalian protein found in Homo sapiens

CD279
programmed cell death 1 protein
programmed cell death protein 1
PDCD1
systemic lupus erythematosus susceptibility 2
Programmed Cell Death 1 Receptor
protein PD-1

Language	Label	Description	Also known as
English	programmed cell death 1	mammalian protein found in Homo sapiens	CD279 programmed cell death 1 protein programmed cell death protein 1 PDCD1 systemic lupus erythematosus susceptibility 2 Programmed Cell Death 1 Receptor protein PD-1

Statements

1 reference

13 November 2019

UniProt protein ID

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15116

Immunoglobulin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15116

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Immunoglobulin subtype, protein family

1 reference

based on heuristic

inferred from protein domain or family

Immunoglobulin V-set domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

immunoglobulin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method or standard

7 references

1 January 2018

HTLV-1 bZIP Factor Enhances T-Cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15116

determination method or standard

1 January 2018

SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15116

determination method or standard

1 January 2018

Structure and Interactions of the Human Programmed Cell Death 1 Receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15116

determination method or standard

1 January 2018

PD-L1 and PD-L2 differ in their molecular mechanisms of interaction with PD-1.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15116

determination method or standard

1 January 2018

A secreted protein microarray platform for extracellular protein interaction discovery

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15116

determination method or standard

1 January 2018

Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15116

determination method or standard

1 January 2018

Porcine PD-L1: cloning, characterization, and implications during xenotransplantation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15116

determination method or standard

signal transducer activity

determination method or standard

1 reference

1 January 2018

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15116&geneProductId=UniProtKB:Q15116

determination method or standard

integral component of membrane

determination method or standard

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15116

determination method or standard

plasma membrane

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15116

determination method or standard

determination method or standard

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15116

determination method or standard

external side of plasma membrane

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15116

determination method or standard

biological process

positive regulation of apoptotic process

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15116

determination method or standard

multicellular organism development

determination method or standard

1 reference

1 January 2018

The human PD-1 gene: complete cDNA, genomic organization, and developmentally regulated expression in B cell progenitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15116

determination method or standard

T cell costimulation

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15116

determination method or standard

negative regulation of apoptotic process

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15116

determination method or standard

positive regulation of T cell apoptotic process

determination method or standard

1 reference

1 January 2018

Mesenchymal stem cells suppress T cells by inducing apoptosis and through PD-1/B7-H1 interactions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15116

determination method or standard

humoral immune response

determination method or standard

1 reference

1 January 2018

The human PD-1 gene: complete cDNA, genomic organization, and developmentally regulated expression in B cell progenitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15116

determination method or standard

negative regulation of tolerance induction

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15116

determination method or standard

immune system process

determination method or standard

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15116

determination method or standard

signal transduction

determination method or standard

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15116&geneProductId=UniProtKB:Q15116

determination method or standard

physically interacts with

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3137343

immunoglobulin V-set domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15116

immunoglobulin-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15116

immunoglobulin subtype

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15116

Identifiers

MeSH descriptor ID

subject named as

Programmed Cell Death 1 Receptor

0 references

D12.776.543.750.705.222.875

0 references

D23.050.301.264.894.790

0 references

D23.101.100.894.790

0 references

D12.776.465.844

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

0 references

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000335062

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000335062

ENSP00000480684

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000480684

ENSP00000487175

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000487175

ENSP00000340808

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000340808

ENSP00000486779

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486779

ENSP00000390296

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000390296

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(16 entries)

arwiki بروتين موت الخلية المبرمج 1
cswiki PD-1
cywiki PDCD1
dewiki Programmed Cell Death Protein 1
enwiki Programmed cell death protein 1
etwiki PD-1
fawiki PD-1
frwiki Protéine 1 de la mort cellulaire programmée
itwiki Proteina 1 della morte cellulare programmata
jawiki PD-1
kowiki PD-1
plwiki Receptor programowanej śmierci 1
ptwiki PD-1
rowiki PD-1
ruwiki PD1
ukwiki PDCD1

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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