deoxyhypusine synthase activity (Q21154359)

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Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+
  • eIF5A-precursor-lysine:spermidine 4-aminobutyltransferase (propane-1,3-diamine-forming) activity
  • eIF-5A-deoxyhypusine synthase activity
  • spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming) activity
  • GO:0034038
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    deoxyhypusine synthase activity
    Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+
    • eIF5A-precursor-lysine:spermidine 4-aminobutyltransferase (propane-1,3-diamine-forming) activity
    • eIF-5A-deoxyhypusine synthase activity
    • spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming) activity
    • GO:0034038

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