Interleukin 12B (Q21120640)

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mammalian protein found in Homo sapiens
  • IL-12 subunit p40
  • interleukin 12, p40
  • interleukin-12 subunit beta
  • interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
  • NK cell stimulatory factor chain 2
  • IL12, subunit p40
  • IL12B
  • interleukin-12 beta chain
  • CLMF p40
  • cytotoxic lymphocyte maturation factor 40 kDa subunit
  • natural killer cell stimulatory factor, 40 kD subunit
  • NKSF2
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Language Label Description Also known as
English
Interleukin 12B
mammalian protein found in Homo sapiens
  • IL-12 subunit p40
  • interleukin 12, p40
  • interleukin-12 subunit beta
  • interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
  • NK cell stimulatory factor chain 2
  • IL12, subunit p40
  • IL12B
  • interleukin-12 beta chain
  • CLMF p40
  • cytotoxic lymphocyte maturation factor 40 kDa subunit
  • natural killer cell stimulatory factor, 40 kD subunit
  • NKSF2

Statements

molecular function
protein binding
determination method or standard
IPI
7 references
retrieved
8 April 2019
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460
determination method or standard
IPI
retrieved
8 April 2019
stated in
A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460
determination method or standard
IPI
retrieved
8 April 2019
stated in
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460
determination method or standard
IPI
retrieved
8 April 2019
stated in
Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460
determination method or standard
IPI
retrieved
8 April 2019
stated in
The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ovine interleukin 12 has biological activity on ovine and human activated peripheral blood mononuclear cells
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460
determination method or standard
IPI
cell component
biological process
positive regulation of interferon-gamma production
determination method or standard
IDA
IEA
5 references
retrieved
27 March 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29460&geneProductId=UniProtKB:P29460
determination method or standard
IEA
retrieved
27 March 2018
stated in
Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor
GOA
curator
UniProt
UniProt protein ID
P29460
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29460&geneProductId=UniProtKB:P29460
determination method or standard
IDA
retrieved
27 March 2018
stated in
Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29460&geneProductId=UniProtKB:P29460
determination method or standard
IDA
retrieved
27 March 2018
stated in
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29460&geneProductId=UniProtKB:P29460
determination method or standard
IDA
retrieved
27 March 2018
stated in
IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29460&geneProductId=UniProtKB:P29460
determination method or standard
IDA
positive regulation of interferon-gamma production
determination method or standard
IBA
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460
determination method or standard
IEA
retrieved
8 April 2019
stated in
Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor
GOA
curator
UniProt
UniProt protein ID
P29460
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460
determination method or standard
IDA
retrieved
8 April 2019
stated in
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460
determination method or standard
IDA
retrieved
8 April 2019
stated in
IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460
determination method or standard
IDA
retrieved
8 April 2019
stated in
Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460
determination method or standard
IBA

Identifiers

MeSH descriptor ID
D053762
subject named as
Interleukin-12 Subunit p40
0 references
 
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