Xaa-Pro dipeptidilna peptidaza
| Xaa-Pro dipeptidilna peptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.14.11 | ||||||||
| CAS broj | 54249-88-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Xaa-Pro dipeptidilna peptidaza (EC 3.4.14.11, X-prolil dipeptidilna aminopeptidaza, PepX, X-prolil dipeptidilna peptidaza, X-Pro dipeptidilna-peptidaza) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza Xaa-Pro veza uz odvajanje neblokiranih, N-terminalnih dipeptida. Supstrati su između ostalog Ala-Pro--p-nitroanilid i (sekvenciono) Tyr-Pro--Phe-Pro--Gly-Pro-Ile
Ovaj intraćelijski enzim iz Laktococcus lactis (190-kDa) pripada peptidaznoj familiji S15.
Reference
[уреди | уреди извор]- ^ Zevaco, C., Monnet, V. and Gripon, J.-C. (1990). „Intracellular X-prolyl dipeptidyl peptidase from Lactococcus lactis' spp. lactis: purification and properties”. J. Appl. Bacteriol. 68: 357—366.
- ^ Meyer-Barton, E.C., Klein, J.R., Imam, M. and Plapp, R. (1993). „Cloning and sequence analysis of the X-prolyl-dipeptidyl-aminopeptidase gene (pepX) from Lactobacillus delbrückii ssp. lactis DSM7290”. Appl. Microbiol. Biotechnol. 40: 82—89. PMID 7765315.
- ^ Habibi-Najafi, M.B. & Lee, B.H. (1994). „Purification and characterization of X-prolyl dipeptidyl peptidase from Lactobacillus casei' subsp. casei LLG”. Appl. Microbiol. Biotechnol. 42: 280—286. PMID 7765768.
- ^ Chich, J.-F., Gripon, J.-C. and Ribadeau-Dumas, B. (1995). „Preparation of bacterial X-prolyl dipeptidyl aminopeptidase and its stabilization by organic cosolvents”. Anal. Biochem. 224: 245—249. PMID 7710078.
- ^ Chich, J.-F., Chapot-Chartier, M.P., Ribadeau-Dumas, B. and Gripon, J.-C. (1995). „Identification of the active site serine of the X-prolyl aminopeptidase from Lactococcus lactis'”. FEBS Lett. 314: 139—142.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- Xaa-Pro+dipeptidyl-peptidase на US National Library of Medicine Medical Subject Headings (MeSH)
