LPHN3
| Latrofilin 3 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | LPHN3; CIRL3; LEC3 | ||||||||||
| Vanjski ID | MGI: 2441950 HomoloGene: 22878 IUPHAR: LPHN3 GeneCards: LPHN3 Gene | ||||||||||
| |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 23284 | 319387 | |||||||||
| Ensembl | ENSG00000150471 | ENSMUSG00000037605 | |||||||||
| UniProt | Q9HAR2 | Q80TS3 | |||||||||
| RefSeq (mRNA) | NM_015236.4 | NM_198702.2 | |||||||||
| RefSeq (protein) | NP_056051.2 | NP_941991.1 | |||||||||
| Lokacija (UCSC) |
Chr 4: 62.07 - 62.94 Mb |
Chr 5: 81.45 - 82.25 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Latrofilin-3 je protein koji je kod ljudi kodiran LPHN3 genom.[1][2]
Function
[уреди | уреди извор]Ovaj protein je član latrofilinske familije G protein spregnutih receptora (GPCR). Latrofilini mogu da učestvuju u ćelijskoj adheziji i u prenosu signala. Endogeno proteolitičko razlaganje unutar cisteinom bogatog GPS (GPCR proteolizno mesto) domena proizvodi dve podjedinice (veliku ekstracelularnu N-terminalnu adhezionu jedinicu i podjedinicu koja je u znatno meri slična sa sekretinskom/kalcitoninskom familijom).[2]
Klinički značaj
[уреди | уреди извор]Jedna verzija ovog gena je povezana sa hiperkinetičkim poremećajem (ADHD).[3]
Reference
[уреди | уреди извор]- ^ Hayflick JS (2001). „A family of heptahelical receptors with adhesion-like domains: a marriage between two super families”. J Recept Signal Transduct Res. 20 (2–3): 119—31. PMID 10994649. doi:10.3109/10799890009150640.
- ^ а б „Entrez Gene: LPHN3 latrophilin 3”.
- ^ Arcos-Burgos M; Jain M; Acosta MT; et al. (2010). „A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication” (PDF). Mol. Psychiatry. 15 (11): 1053—66. PMID 20157310. doi:10.1038/mp.2010.6.[мртва веза]
Literatura
[уреди | уреди извор]- Südhof TC (2001). „alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins”. Annu. Rev. Neurosci. 24: 933—62. PMID 11520923. doi:10.1146/annurev.neuro.24.1.933.
- Ushkaryov YA, Volynski KE, Ashton AC (2004). „The multiple actions of black widow spider toxins and their selective use in neurosecretion studies”. Toxicon. 43 (5): 527—42. PMID 15066411. doi:10.1016/j.toxicon.2004.02.008.
- Soares MB; Bonaldo MF; Jelene P; et al. (1994). „Construction and characterization of a normalized cDNA library”. Proc. Natl. Acad. Sci. U.S.A. 91 (20): 9228—32. PMC 44785
. PMID 7937745. doi:10.1073/pnas.91.20.9228. - „Toward a complete human genome sequence”. Genome Res. 8 (11): 1097—108. 1999. PMID 9847074. doi:10.1101/gr.8.11.1097.
- Nagase T; Ishikawa K; Suyama M; et al. (1999). „Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro”. DNA Res. 5 (5): 277—86. PMID 9872452. doi:10.1093/dnares/5.5.277.
- Kreienkamp HJ; Zitzer H; Gundelfinger ED; et al. (2000). „The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins”. J. Biol. Chem. 275 (42): 32387—90. PMID 10964907. doi:10.1074/jbc.C000490200.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Ota T; Suzuki Y; Nishikawa T; et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40—5. PMID 14702039. doi:10.1038/ng1285.
- Bjarnadóttir TK; Fredriksson R; Höglund PJ; et al. (2005). „The human and mouse repertoire of the adhesion family of G-protein-coupled receptors”. Genomics. 84 (1): 23—33. PMID 15203201. doi:10.1016/j.ygeno.2003.12.004.