Fukoziltransferasa 3
Galaktozid 3(4)-L-fukoziltransferaza je enzim koji je kod ljudi kodiran FUT3 genom.[1][2][3]
Funkcija
[уреди | уреди извор]Levisov sistem histo-krvnih grupa obuhvata skup fukozilovanih glikosfingolipida koji se sintetišu u egzokrinim epitelnim ćelijama i cirkulišu u telesnim tečnostima. Glikosfingolipidi funkcionišu u embriogenezi, diferencijaciji tkiva, metastazama tumora, zapaljenju i bakterijskoj adheziji. Oni se sekundarno apsorbuju u crvena krvna zrnca što dovodi do njihovog Luisovog fenotipa. Ovaj gen je član porodice fukoziltransferaza, koja katalizuje dodavanje fukoze na prekurzor polisaharida u poslednjem koraku biosinteze Luisovog antigena. On kodira enzim sa aktivnostima alfa(1,3)-fukoziltransferaze i alfa(1,4)-fukoziltransferaze. Mutacije u ovom genu su odgovorne za većinu Levis antigen-negativnih fenotipova. Za ovaj gen je pronađeno više alternativnih splajsnih varijanti, koje kodiraju isti protein.[3]
Vidi još
[уреди | уреди извор]Reference
[уреди | уреди извор]- ^ Kukowska-Latallo JF, Larsen RD, Nair RP, Lowe JB (август 1990). „A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase”. Genes & Development. 4 (8): 1288—303. PMID 1977660. doi:10.1101/gad.4.8.1288 .
- ^ Weston BW, Nair RP, Larsen RD, Lowe JB (фебруар 1992). „Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities”. The Journal of Biological Chemistry. 267 (6): 4152—60. PMID 1740457. doi:10.1016/S0021-9258(19)50641-X .
- ^ а б „Entrez Gene: FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)”.
Literatura
[уреди | уреди извор]- Cameron HS, Szczepaniak D, Weston BW (август 1995). „Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms”. The Journal of Biological Chemistry. 270 (34): 20112—22. PMID 7650030. doi:10.1074/jbc.270.34.20112 .
- Reguigne-Arnould I, Couillin P, Mollicone R, Fauré S, Fletcher A, Kelly RJ, Lowe JB, Oriol R (1995). „Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19”. Cytogenetics and Cell Genetics. 71 (2): 158—62. PMID 7656588. doi:10.1159/000134098.
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Spoljašnje veze
[уреди | уреди извор]- CD174+Antigen на US National Library of Medicine Medical Subject Headings (MeSH)