Alnespiron

Alnespiron
IUPAC ime
	(+)-4-dihidro-2H-hromen-3-il]-propilamino]butil]-8-azaspiro[4.5]dekan-7,9-dion
Identifikatori
CAS broj	143413-68-7
ATC kod	none
PubChem	CID 178132
ChemSpider	8002134
UNII	34E28BM822
Hemijski podaci
Formula	C26H38N2O4
Molarna masa	442,589 g/mol
	SMILES Cl.O=C1N(C(=O)CC2(C1)CCCC2)CCCCN([C@H]3Cc4c(OC)cccc4OC3)CCC; ;
	InChI InChI=1S/C26H38N2O4.ClH/c1-3-13-27(20-16-21-22(31-2)9-8-10-23(21)32-19-20)14-6-7-15-28-24(29)17-26(18-25(28)30)11-4-5-12-26;/h8-10,20H,3-7,11-19H2,1-2H3;1H/t20-;/m0./s1 ; Key:QYFHCFNBYQZGKW-BDQAORGHSA-N ;

Alnespiron (S-20,499) je selektivni pun agonist 5-HT_1A receptora iz azapironske hemijske klase.^[1]^[2]^[3] On ima antidepresivne i anksiolitičke efekte.^[1]

Reference

^ ^а ^б Griebel G, Misslin R, Pawlowski M, Guardiola Lemaître B, Guillaumet G, Bizot-Espiard J (1992). „Anxiolytic-like effects of a selective 5-HT1A agonist, S20244, and its enantiomers in mice.”. Neuroreport. 3 (1): 84—86. PMID 1351756. doi:10.1097/00001756-199201000-00022.
^ Simon P, Guardiola B, Bizot-Espiard J, Schiavi P, Costentin J (1992). „5-HT1A receptor agonists prevent in rats the yawning and penile erections induced by direct dopamine agonists.”. Psychopharmacology (Berl). 108 (1-2): 47—50. PMID 1357709. doi:10.1007/BF02245284.
^ Astier B, Lambás Señas L, Soulière F, Schmitt P, Urbain N, Rentero N, Bert L, Denoroy L, Renaud B, Lesourd M, Muñoz C, Chouvet G (2003). „In vivo comparison of two 5-HT1A receptors agonists alnespirone (S-20499) and buspirone on locus coeruleus neuronal activity.”. Eur J Pharmacol. 459 (1): 17—26. PMID 12505530. doi:10.1016/S0014-2999(02)02814-5.