User:Mr. Ibrahem/Nepafenac

Mr. Ibrahem/Nepafenac

Clinical data
Trade names	Nevanac, Ilevro, Amnac, others
AHFS/Drugs.com	Monograph
MedlinePlus	a606007
License data	EU EMA: by INN US DailyMed: Nepafenac
Pregnancy category	AU: C[1]
Routes of administration	Eye drops
Drug class	NSAID
Legal status
Legal status	US: ℞-only In general: ℞ (Prescription only)
Identifiers
IUPAC name 2-amino-3-benzoylbenzeneacetamide
Chemical and physical data
Formula	C15H14N2O2
Molar mass	254.29 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(c1cccc(c1N)CC(=O)N)c2ccccc2
InChI InChI=1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18) Y Key:QEFAQIPZVLVERP-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Nepafenac, sold under the brand name Nevanac among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation associated with cataract surgery.^[2] It is used as an eye drop.^[2]

Common side effects include irritation of the eye.^[2] Other side effects may include keratitis and hyphema.^[3] It works by inhibiting COX-1 and COX-2 and therefore decreasing prostaglandins.^[3][2]

Nepafenac was approved for medical use in the United States in 2005 and Europe in 2007.^[3][2] In the United Kingdom a bottle costs the NHS about £15 as of 2021.^[4] In the United States this amount costs about 290 USD.^[5]

1. ↑ ^{1.0 1.1} "Nepafenac ophthalmic Use During Pregnancy". Drugs.com. 6 June 2019. Archived from the original on 25 January 2021. Retrieved 13 September 2020.
2. ↑ ^{2.0 2.1 2.2 2.3 2.4 2.5 2.6} "Nevanac". Archived from the original on 7 July 2020. Retrieved 12 November 2021.
3. ↑ ^{3.0 3.1 3.2} "Nepafenac Monograph for Professionals". Drugs.com. Archived from the original on 22 April 2016. Retrieved 12 November 2021.
4. ↑ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1206. ISBN 978-0857114105.
5. ↑ "Nevanac Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 27 May 2020. Retrieved 12 November 2021.