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Ubikvitin C

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Ubikvitin C

PDB prikaz baziran na 1aar.
Dostupne strukture
1aar, 1cmx, 1d3z, 1f9j, 1fxt, 1g6j, 1gjz, 1nbf, 1ogw, 1otr, 1p3q, 1q0w, 1q5w, 1s1q, 1sif, 1tbe, 1ubi, 1ubq, 1ud7, 1uzx, 1v80, 1v81, 1wr1, 1wr6, 1wrd, 1xd3, 1xqq, 1yd8, 1yiw, 1yj1, 1yx5, 1yx6, 1zgu, 2ayo, 2bgf, 2c7m, 2c7n, 2d3g, 2den, 2dx5, 2fcm, 2fcn, 2fcq, 2fcs, 2fid, 2fif, 2fuh, 2g3q, 2g45, 2gbj, 2gbk, 2gbm, 2gbn, 2gbr, 2gmi, 2hd5, 2hth, 2ibi, 2j7q, 2nr2, 2o6v, 2oob
Identifikatori
SimboliUBC; HMG20
Vanjski IDOMIM191340 MGI98889 HomoloGene39626 GeneCards: UBC Gene
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez731622190
EnsemblENSG00000150991ENSMUSG00000008348
UniProtP0CG48Q3TH47
RefSeq (mRNA)XM_001132949XM_001001910
RefSeq (protein)XP_001132949XP_001001910
Lokacija (UCSC)Chr 12:
123.96 - 123.97 Mb
Chr 5:
125.68 - 125.68 Mb
PubMed pretraga[1][2]

Ubikvitin je protein koji je kod čoveka kodiran UBC genom.[1][2][3]

Interakcije

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Za ubikvitin C je pokazano da interaguje sa SCNN1A,[4][5] SCNN1G,[4][5] Parkin (ligazom),[6][7] P70-S6 kinazom 1,[8] TRAF6,[9][10][11][12][13] HDAC3,[14] SFPQ,[15] S100A10,[16] SMAD3,[17][18] NOTCH1,[19] HIF1A,[20][21][22] receptorom epidermalnog faktora rasta,[23][24][25] E2F1,[26] Basigin,[27] IRAK1,[9][12][28][29] NFE2L2,[30][31] RIPK1,[9][13][32][33][34] Mdm2,[35][36][37] Kapa opioidnim receptorom,[38] NUAK1,[39] BIRC2,[33][40][41] tiroidnim hormonskim receptorom alfa,[14] Sp1 transkriptnim faktorom,[42] SMURF2,[43][44] MARK4,[39] Cdk1,[14] PCNA[45][46][47] i P53.[23][35][36][37][48][49][50][51]

Reference

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  2. Marinovic AC, Zheng B, Mitch WE, Price SR (May 2002). „Ubiquitin (UbC) expression in muscle cells is increased by glucocorticoids through a mechanism involving Sp1 and MEK1”. J Biol Chem 277 (19): 16673–81. DOI:10.1074/jbc.M200501200. PMID 11872750. 
  3. „Entrez Gene: UBC ubiquitin C”. 
  4. 4,0 4,1 Boulkroun, Sheerazed; Ruffieux-Daidié Dorothée, Vitagliano Jean-Jacques, Poirot Olivier, Charles Roch-Philippe, Lagnaz Dagmara, Firsov Dmitri, Kellenberger Stephan, Staub Olivier (October 2008). „Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3”. Am. J. Physiol. Renal Physiol. (United States) 295 (4): F889–900. DOI:10.1152/ajprenal.00001.2008. ISSN 0363-6127. PMID 18632802. 
  5. 5,0 5,1 Raikwar, Nandita S; Thomas Christie P (May 2008). „Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel”. Am. J. Physiol. Renal Physiol. (United States) 294 (5): F1157–65. DOI:10.1152/ajprenal.00339.2007. ISSN 0363-6127. PMC 2424110. PMID 18322022. 
  6. Yu, Furong; Zhou Jianhua (July 2008). „Parkin is ubiquitinated by Nrdp1 and abrogates Nrdp1-induced oxidative stress”. Neurosci. Lett. (Ireland) 440 (1): 4–8. DOI:10.1016/j.neulet.2008.05.052. ISSN 0304-3940. PMID 18541373. 
  7. Kawahara, Kohichi; Hashimoto Makoto, Bar-On Pazit, Ho Gilbert J, Crews Leslie, Mizuno Hideya, Rockenstein Edward, Imam Syed Z, Masliah Eliezer (March 2008). „alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease”. J. Biol. Chem. (United States) 283 (11): 6979–87. DOI:10.1074/jbc.M710418200. ISSN 0021-9258. PMID 18195004. 
  8. Panasyuk, Ganna; Nemazanyy Ivan, Filonenko Valeriy, Gout Ivan (May 2008). „Ribosomal protein S6 kinase 1 interacts with and is ubiquitinated by ubiquitin ligase ROC1”. Biochem. Biophys. Res. Commun. (United States) 369 (2): 339–43. DOI:10.1016/j.bbrc.2008.02.016. PMID 18279656. 
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  25. Umebayashi, Kyohei; Stenmark Harald, Yoshimori Tamotsu (August 2008). „Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation”. Mol. Biol. Cell (United States) 19 (8): 3454–62. DOI:10.1091/mbc.E07-10-0988. PMC 2488299. PMID 18508924. 
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  27. Wang, Wen-Juan; Li Qing-Quan, Xu Jing-Da, Cao Xi-Xi, Li Hai-Xia, Tang Feng, Chen Qi, Yang Jin-Ming, Xu Zu-De, Liu Xiu-Ping (2008). „Interaction between CD147 and P-glycoprotein and their regulation by ubiquitination in breast cancer cells”. Chemotherapy (Switzerland) 54 (4): 291–301. DOI:10.1159/000151225. PMID 18689982. 
  28. Xiao, Hui; Qian Wen, Staschke Kirk, Qian Youcun, Cui Grace, Deng Li, Ehsani Mariam, Wang Xiliang, Qian Yue-Wei, Chen Zhijian J, Gilmour Raymond, Jiang Zhengfan, Li Xiaoxia (May 2008). „Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kappaB activation”. J. Biol. Chem. (United States) 283 (21): 14654–64. DOI:10.1074/jbc.M706931200. ISSN 0021-9258. PMC 2386918. PMID 18326498. 
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Literatura

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