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Propentofilin

Izvor: Wikipedija
Propentofilin
(IUPAC) ime
3-metil-1-(5-oksoheksil)-7-propil-3,7-dihidro-1H-purin-2,6-dion
Klinički podaci
AHFS/Drugs.com Internacionalno ime leka
Identifikatori
CAS broj 55242-55-2
ATC kod N06BC02 QC04AD90
PubChem[1][2] 4938
UNII 5RTA398U4H DaY
Hemijski podaci
Formula C15H22N4O3 
Mol. masa 306,360 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Propentofilin (HWA 285) je ksantinski derivat sa mogućim neuroprotektivnim dejstvom.

Farmakologija

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On je inhibitor fosfodiesteraze.[3] On takođe deluje kao inhibitor preuzimanja adenozina.[4][5][6]

Upotreba

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On je izučavan za moguću primenu u tretiranju Alchajimerove bolesti i vaskularne demencije.[7][8]

Reference

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  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Frampton M, Harvey RJ, Kirchner V (2003). Frampton, Maria A. ur. „Propentofylline for dementia”. Cochrane Database Syst Rev (2): CD002853. DOI:10.1002/14651858.CD002853. PMID 12804440. 
  4. Frampton M, Harvey RJ, Kirchner V (2003). Frampton, Maria A. ur. „Propentofylline for dementia”. Cochrane Database Syst Rev (2): CD002853. DOI:10.1002/14651858.CD002853. PMID 12804440. 
  5. Salimi S, Fotouhi A, Ghoreishi A i dr.. (April 2008). „A placebo controlled study of the propentofylline added to risperidone in chronic schizophrenia”. Prog. Neuropsychopharmacol. Biol. Psychiatry 32 (3): 726–732. DOI:10.1016/j.pnpbp.2007.11.021. PMID 18096287. 
  6. Numagami Y, Marro PJ, Mishra OP, Delivoria-Papadopoulos M (June 1998). „Effect of propentofylline on free radical generation during cerebral hypoxia in the newborn piglet”. Neuroscience 84 (4): 1127–1133. DOI:10.1016/S0306-4522(97)00542-3. PMID 9578400. 
  7. Frampton M, Harvey RJ, Kirchner V (2003). Frampton, Maria A. ur. „Propentofylline for dementia”. Cochrane database of systematic reviews (Online) (2): CD002853. DOI:10.1002/14651858.CD002853. PMID 12804440. 
  8. Kittner B, Rössner M, Rother M (1997). „Clinical trials in dementia with propentofylline”. Ann. N. Y. Acad. Sci. 826: 307–316. DOI:10.1111/j.1749-6632.1997.tb48481.x. PMID 9329701. 

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