Nalmekson

Nalmekson
(IUPAC) ime
	(5α)-3,14-dihidroksi-17-(3-metil-2-buten-1-il)-4,5-epoksimorfinan-6-on
Klinički podaci
Identifikatori
CAS broj	16676-26-9 ; 16291-05-7 (HCl)
ATC kod	nije dodeljen
PubChem	5360516
ChemSpider	4514525
Hemijski podaci
Formula	C21H25NO4
Mol. masa	355,428 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C21H25NO4/c1-12(2)6-9-22-10-8-20-17-13-3-4-14(23)18(17)26-19(20)15(24)5-7-21(20,25)16(22)11-13/h3-4,6,16,19,23,25H,5,7-11H2,1-2H3/t16-,19+,20+,21-/m1/s1 ; Key: OHKCLOQPSLQCQR-MBPVOVBZSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Nalmekson (INN; EN-1620A, UM-592, nalmekson hidrohlorid) je semisintetički, mešoviti opioidni agonist-antagonist sa analgetičkim i narkotičnim svojstvima.^[4]^[5]^[6]^[7] U kliničkim ispitivanjima utvrđeno je da ima analgetičku efikastnost sličnu morfinu, mada sa nekoliko puta umanjenom potentnošću.^[8] Osim toga, nuspojave nalmeksona su pospanost i znojenje, slično morfinu, mada u znatnom većem stepenu i učestalošću.^[8]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ F.. Macdonald (1997). Dictionary of Pharmacological Agents. CRC Press. str. 1395. ISBN 978-0-412-46630-4. Pristupljeno 11. 5. 2012.
↑ Casy, Alan F.; Parfitt, Robert T. (1986). Opioid Analgesics: Chemistry and Receptors. Springer. str. 55. ISBN 978-0-306-42130-3. Pristupljeno 11. 5. 2012.
↑ Loew GH, Berkowitz DS (January 1978). „Quantum chemical studies of N-substituent variation in the oxymorphone series of opiate narcotics”. Journal of Medicinal Chemistry 21 (1): 101–6. PMID 73588.
↑ Forrest WH, Shroff PF, Mahler DL (1972). „Analgesic and other effects of nalmexone in man”. Clinical Pharmacology and Therapeutics 13 (4): 520–5. PMID 4557582.
↑ ^8,0 ^8,1 National Research Council (U.S.). Committee on Problems of Drug Dependence; American Medical Association. Committee on Alcoholism and Drug Dependence; American Medical Association. Council on Mental Health; National Academy of Sciences (U.S.) (1969*). Bulletin, problems of drug dependence. National Academies. str. 5873. NAP:10503. Pristupljeno 11. 5. 2012.

Literatura

National Research Council (U.S.). Committee on Problems of Drug Dependence; American Medical Association. Committee on Alcoholism and Drug Dependence; American Medical Association. Council on Mental Health; National Academy of Sciences (U.S.) (1969*). Bulletin, problems of drug dependence. National Academies. str. 5873. NAP:10503. Pristupljeno 11. 5. 2012.
Casy, Alan F.; Parfitt, Robert T. (1986). Opioid Analgesics: Chemistry and Receptors. Springer. str. 55. ISBN 978-0-306-42130-3. Pristupljeno 11. 5. 2012.
F.. Macdonald (1997). Dictionary of Pharmacological Agents. CRC Press. str. 1395. ISBN 978-0-412-46630-4. Pristupljeno 11. 5. 2012.

Povezano

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[Macdonald1997-4] F.. Macdonald (1997). Dictionary of Pharmacological Agents. CRC Press. str. 1395. ISBN 978-0-412-46630-4. Pristupljeno 11. 5. 2012.

[CasyParfitt1986-5] Casy, Alan F.; Parfitt, Robert T. (1986). Opioid Analgesics: Chemistry and Receptors. Springer. str. 55. ISBN 978-0-306-42130-3. Pristupljeno 11. 5. 2012.

[pmid73588-6] Loew GH, Berkowitz DS (January 1978). „Quantum chemical studies of N-substituent variation in the oxymorphone series of opiate narcotics”. Journal of Medicinal Chemistry 21 (1): 101–6. PMID 73588.

[pmid4557582-7] Forrest WH, Shroff PF, Mahler DL (1972). „Analgesic and other effects of nalmexone in man”. Clinical Pharmacology and Therapeutics 13 (4): 520–5. PMID 4557582.

[DependenceDependence1969-8] 8,0 ^8,1 National Research Council (U.S.). Committee on Problems of Drug Dependence; American Medical Association. Committee on Alcoholism and Drug Dependence; American Medical Association. Council on Mental Health; National Academy of Sciences (U.S.) (1969*). Bulletin, problems of drug dependence. National Academies. str. 5873. NAP:10503. Pristupljeno 11. 5. 2012.

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