Interleukin 27

Epštajn-Barov virus indukovan 3
Identifikatori
Simbol	EBI3
Alt. simboli	IL-27B
Entrez	10148
Hugo	3129
OMIM	605816
RefSek	NM_005755
UniProt	Q14213
Drugi podaci
Lokus	Hrom. 19 p13

Interleukin 27
Identifikatori
Simbol	IL27
Alt. simboli	IL30, p28
Entrez	246778
Hugo	19157
OMIM	608273
RefSek	NM_145659
UniProt	Q6P676
Drugi podaci
Lokus	Hrom. 16 p11

Interleukin 27 (IL-27) je heterodimerični citokin koji pripada IL-12 familiji koja se sastoji od dve pod-jedinice, Epštajn-Barov virus (EBV)-indukovani gen 3 (EBI3) (isto poznat kao IL-27B) i IL27-p28 (poznat kao IL-30).^[1] IL-27 proizvode antigen-prezentirajuće ćelije.^[2] IL-27 igra važnu ulogu u regulisanju aktivnosti B i T limfocita.^[3] IL-27 efekti su izazvani njegovom interakcijom sa specifičnim receptorskim kompleksom na ćelijskoj površini koji se sastoji od dva proteina poznata kao IL27R i gp130.^[4]^[5]^[6]

Reference

↑ Larousserie, F; Bardel, E; Pflanz, S; Arnulf, B; Lome-Maldonado, C; Hermine, O; Brégeaud, L; Perennec, M i dr.. (April 2005). „Analysis of interleukin-27 (EBI3/p28) expression in Epstein-Barr virus- and human T-cell leukemia virus type 1-associated lymphomas: heterogeneous expression of EBI3 subunit by tumoral cells”. The American Journal of Pathology 166 (4): 1217–28. PMC 1602381. PMID 15793300. Arhivirano iz originala na datum 2009-04-14. Pristupljeno 2014-05-23.
↑ Lucas S, Ghilardi N, Li J, de Sauvage FJ (December 2003). „IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms”. Proceedings of the National Academy of Sciences of the United States of America 100 (25): 15047–52. DOI:10.1073/pnas.2536517100. PMC 299900. PMID 14657353.
↑ Larousserie F, Charlot P, Bardel E, Froger J, Kastelein RA, Devergne O (May 2006). „Differential effects of IL-27 on human B cell subsets”. Journal of Immunology (Baltimore, Md. : 1950) 176 (10): 5890–7. PMID 16670296.
↑ Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF, Phillips JH, McClanahan TK, de Waal Malefyt R, Kastelein RA (February 2004). „WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27”. Journal of immunology (Baltimore, Md. : 1950) 172 (4): 2225–31. PMID 14764690.
↑ Thomas J. Kindt, Richard A. Goldsby, Barbara Anne Osborne, Janis Kuby (2006). Kuby Immunology (6 izd.). New York: W H Freeman and company. ISBN 1-4292-0211-4.
↑ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.

Spoljašnje veze

MeSH Interleukin-27

Wikimedia Commons ima još multimedijalnih datoteka vezanih za: Interleukin 27

[pmid15793300-1] Larousserie, F; Bardel, E; Pflanz, S; Arnulf, B; Lome-Maldonado, C; Hermine, O; Brégeaud, L; Perennec, M i dr.. (April 2005). „Analysis of interleukin-27 (EBI3/p28) expression in Epstein-Barr virus- and human T-cell leukemia virus type 1-associated lymphomas: heterogeneous expression of EBI3 subunit by tumoral cells”. The American Journal of Pathology 166 (4): 1217–28. PMC 1602381. PMID 15793300. Arhivirano iz originala na datum 2009-04-14. Pristupljeno 2014-05-23.

[pmid14657353-2] Lucas S, Ghilardi N, Li J, de Sauvage FJ (December 2003). „IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms”. Proceedings of the National Academy of Sciences of the United States of America 100 (25): 15047–52. DOI:10.1073/pnas.2536517100. PMC 299900. PMID 14657353.

[pmid16670296-3] Larousserie F, Charlot P, Bardel E, Froger J, Kastelein RA, Devergne O (May 2006). „Differential effects of IL-27 on human B cell subsets”. Journal of Immunology (Baltimore, Md. : 1950) 176 (10): 5890–7. PMID 16670296.

[pmid14764690-4] Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF, Phillips JH, McClanahan TK, de Waal Malefyt R, Kastelein RA (February 2004). „WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27”. Journal of immunology (Baltimore, Md. : 1950) 172 (4): 2225–31. PMID 14764690.

[KubyImmunology6th-5] Thomas J. Kindt, Richard A. Goldsby, Barbara Anne Osborne, Janis Kuby (2006). Kuby Immunology (6 izd.). New York: W H Freeman and company. ISBN 1-4292-0211-4.

[6] Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.

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