Haplogroup L5
| Haplogroup L5 | |
|---|---|
| Possible time of origin | 114,200-126,200 YBP[1] |
| Possible place of origin | East Africa, Upper Nile Valley |
| Ancestor | L2-6 |
| Descendants | L5a, L5c |
| Defining mutations | 3423, 7972, 12432, 12950[2] |
Haplogroup L5 is a human mitochondrial DNA (mtDNA) clade. It was previously known as L1e.
Distribution
[edit]L5 is a small haplogroup centered in East Africa. The highest frequency is in Mbuti Pygmies from Eastern Central Africa at 15%.[3] It is present in relatively small frequencies in Tanzania (Sandawe and others), Kenya, Chad, Ethiopia, Sudan, Nubia, Egypt[4][Note 1] and Saudi Arabia.[5]
Haplogroup L5 has been observed among specimens at the island cemetery in Kulubnarti, Sudan, which date from the Early Christian period (AD 550–800).[6]
Subclades
[edit]Tree
[edit]This phylogenetic tree of haplogroup L5 subclades is based on the paper by Mannis van Oven and Manfred Kayser Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation[2] and subsequent published research.
- Most Recent Common Ancestor (MRCA)
- L1-6
- L2-6
- L5
- L5a
- L5a1
- L5a1a
- L5a1b
- L5a1c
- L5a2
- L5a1
- L5c
- L5c1
- L5c2
- L5a
- L5
- L2-6
- L1-6
References
[edit]- ^ Soares, P; Ermini, L; Thomson, N; Mormina, M; Rito, T; Röhl, A; Salas, A; Oppenheimer, S; MacAulay, V (2009). "Correcting for Purifying Selection: An Improved Human Mitochondrial Molecular Clock". American Journal of Human Genetics. 84 (6): 740–59. doi:10.1016/j.ajhg.2009.05.001. PMC 2694979. PMID 19500773.
- ^ a b van Oven, Mannis; Manfred Kayser (13 Oct 2008). "Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation". Human Mutation. 30 (2): E386–E394. doi:10.1002/humu.20921. PMID 18853457. S2CID 27566749.
- ^ Sarah A. Tishkoff et al. 2007, History of Click-Speaking Populations of Africa Inferred from mtDNA and Y Chromosome Genetic Variation. Molecular Biology and Evolution 2007 24(10):2180-2195
- ^ Stevanovitch, A; A. Gilles; E. Bouzaid; R. Kefi; F. Paris; R. P. Gayraud; J. L. Spadoni; F. El-Chenawi; E. Béraud-Colomb (29 Jan 2004). "Mitochondrial DNA Sequence Diversity in a Sedentary Population from Egypt". Annals of Human Genetics. 68 (1): 23–39. doi:10.1046/j.1529-8817.2003.00057.x. PMID 14748828. S2CID 44901197.
- ^ Abu-Amero et al. 2008 February. "Mitochondrial DNA structure in the Arabian Peninsula", BMC Evolutionary Biology. 8(45): 52.
- ^ Sirak, Kendra; Frenandes, Daniel; Novak, Mario; Van Gerven, Dennis; Pinhasi, Ron (2016). "Abstract Book of the IUAES Inter-Congress 2016 - A community divided? Revealing the community genome(s) of Medieval Kulubnarti using next- generation sequencing". Abstract Book of the Iuaes Inter-Congress 2016. IUAES: 115.
Notes
[edit]- ^ Sample UPE52 is subclade L5a.
External links
[edit]
- General
- Mannis van Oven's Phylotree
- Haplogroup L5
- Ian Logan's Haplogroup L5
- YFull MTree's Haplogroup L5
- MITOMAP's Haplogroup L5
|
Phylogenetic tree of human mitochondrial DNA (mtDNA) haplogroups | |||||||||||||||||||||||||||||||||||||||
| Mitochondrial Eve (L) | |||||||||||||||||||||||||||||||||||||||
| L0 | L1–6 | ||||||||||||||||||||||||||||||||||||||
| L1 | L2 | L3 | L4 | L5 | L6 | ||||||||||||||||||||||||||||||||||
| M | N | ||||||||||||||||||||||||||||||||||||||
| CZ | D | E | G | Q | O | A | S | R | I | W | X | Y | |||||||||||||||||||||||||||
| C | Z | B | F | R0 | pre-JT | P | U | ||||||||||||||||||||||||||||||||
| HV | JT | K | |||||||||||||||||||||||||||||||||||||
| H | V | J | T | ||||||||||||||||||||||||||||||||||||
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