Aldolasis

Aldolases (diligentius Fructoso-1,6-bis-phosphati-aldolasis) (Numeri EC: 4.1.2.13) sunt familia trium enzymorum: quae aldolasis A enim, aldolasis B, et aldolasis C dicuntur.

Enzymum aldolasis est pars glycolysis quo reactionem quarta, a fructoso-bisphosphato ad glyceraldehydro-3-phosphatum et dihydroxyacetonophosphatum perficit:

D-fructoso-1,6-bis-phosphatum ${\displaystyle \rightleftharpoons }$ di-hydroxy-acetono phosphatum + D-glyceraldehydo-3-phosphatum

In cellulis aldolasis etiam cum H⁺-ATPasi (ATP + H
₂O + H⁺
_introrsum ${\displaystyle \rightleftharpoons }$ ADP + phosphate + H⁺
_extrorsum) interagit^[1].

Aldolum in chemia est verbum amalgamatum ex gregibus chemicis aldehydi et alcoholum compositum est.

Tres isoformae notae sunt, A (muscularis), B (hepatica), C (cerebralis).

Aldolasis A in musculis reperiuntur. In hominibus genum nomine ALDOA chromosomate 16 (16p11.2) locatum est.

Aldolasis B in iecore reperiuntur. In hominibus genum nomine ALDOB chromosomate 9 (9q31.1) locatum est. Gradus eius activus ab statu nutritivo pendet: parvus in fame, magnus post cibum^[2].

Aldolasis C in cerebro (hippocampo) reperiuntur. In hominibus genum nomine ALDOC chromosomate 17 (17q11.2) locatum est.

• 
  D-fructoso-1,6-bis-phosphatum
• 
  D-glyceraldehydro-3-phosphatum
• 
  Di-hydroxy-acetono phosphatum