CCR5

CCR5, (bahasa Inggris: chemokine receptor 5, CCR5) adalah pencerap kemokina dengan ligan, antara lain berupa RANTES, MIP-1α dan MIP-1β. CCR5 juga merupakan nama dari gen yang mengkodekan dari reseptor CC45. CCR5 terletak pada kromosom 3 pada lengan pendek (p) pada posisi 21. CCR5 terutama ada pada sel T, makrofaga, sel dendritik dan mikroglia. CCR5 memainkan peran penting pada respon peradangan terhadap infeksi, walaupun peran CCR5 untuk fungsi imun masih tidak jelas. HIV menggunakan CCR5 atau protein lainnya, CXCR4, untuk memasuki sel targetnya.

Referensi

Wilkinson D (1997). "Cofactors provide the entry keys. HIV-1". Curr. Biol. 6 (9): 1051–3. PMID 8805353.
Broder CC, Dimitrov DS (1997). "HIV and the 7-transmembrane domain receptors". Pathobiology. 64 (4): 171–9. PMID 9031325.
Choe H, Martin KA, Farzan M; et al. (1998). "Structural interactions between chemokine receptors, gp120 Env and CD4". Semin. Immunol. 10 (3): 249–57. PMID 9653051.
Sheppard HW, Celum C, Michael NL; et al. (2002). "HIV-1 infection in individuals with the CCR5-Delta32/Delta32 genotype: acquisition of syncytium-inducing virus at seroconversion". J. Acquir. Immune Defic. Syndr. 29 (3): 307–13. PMID 11873082.
Freedman BD, Liu QH, Del Corno M, Collman RG (2004). "HIV-1 gp120 chemokine receptor-mediated signaling in human macrophages". Immunol. Res. 27 (2-3): 261–76. PMID 12857973.
Esté JA (2004). "Virus entry as a target for anti-HIV intervention". Curr. Med. Chem. 10 (17): 1617–32. PMID 12871111.
Gallo SA, Finnegan CM, Viard M; et al. (2003). "The HIV Env-mediated fusion reaction". Biochim. Biophys. Acta. 1614 (1): 36–50. PMID 12873764.
Zaitseva M, Peden K, Golding H (2003). "HIV coreceptors: role of structure, posttranslational modifications, and internalization in viral-cell fusion and as targets for entry inhibitors". Biochim. Biophys. Acta. 1614 (1): 51–61. PMID 12873765.
Lee C, Liu QH, Tomkowicz B; et al. (2004). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". J. Leukoc. Biol. 74 (5): 676–82. doi:10.1189/jlb.0503206. PMID 12960231.
Yi Y, Lee C, Liu QH; et al. (2004). "Chemokine receptor utilization and macrophage signaling by human immunodeficiency virus type 1 gp120: Implications for neuropathogenesis". J. Neurovirol. 10 Suppl 1: 91–6. PMID 14982745.
Seibert C, Sakmar TP (2004). "Small-molecule antagonists of CCR5 and CXCR4: a promising new class of anti-HIV-1 drugs". Curr. Pharm. Des. 10 (17): 2041–62. PMID 15279544.
Cutler CW, Jotwani R (2006). "Oral mucosal expression of HIV-1 receptors, co-receptors, and alpha-defensins: tableau of resistance or susceptibility to HIV infection?". Adv. Dent. Res. 19 (1): 49–51. PMID 16672549.
Ajuebor MN, Carey JA, Swain MG (2006). "CCR5 in T cell-mediated liver diseases: what's going on?". J. Immunol. 177 (4): 2039–45. PMID 16887960.
Lipp M, Müller G (2006). "Shaping up adaptive immunity: the impact of CCR7 and CXCR5 on lymphocyte trafficking". Verhandlungen der Deutschen Gesellschaft für Pathologie. 87: 90–101. PMID 16888899.
Balistreri CR, Caruso C, Grimaldi MP; et al. (2007). "CCR5 receptor: biologic and genetic implications in age-related diseases". Ann. N. Y. Acad. Sci. 1100: 162–72. doi:10.1196/annals.1395.014. PMID 17460174.
Madsen HO, Poulsen K, Dahl O; et al. (1990). "Retropseudogenes constitute the major part of the human elongation factor 1 alpha gene family". Nucleic Acids Res. 18 (6): 1513–6. PMID 2183196.
Uetsuki T, Naito A, Nagata S, Kaziro Y (1989). "Isolation and characterization of the human chromosomal gene for polypeptide chain elongation factor-1 alpha". J. Biol. Chem. 264 (10): 5791–8. PMID 2564392.
Whiteheart SW, Shenbagamurthi P, Chen L; et al. (1989). "Murine elongation factor 1 alpha (EF-1 alpha) is posttranslationally modified by novel amide-linked ethanolamine-phosphoglycerol moieties. Addition of ethanolamine-phosphoglycerol to specific glutamic acid residues on EF-1 alpha". J. Biol. Chem. 264 (24): 14334–41. PMID 2569467.
Ann DK, Wu MM, Huang T; et al. (1988). "Retinol-regulated gene expression in human tracheobronchial epithelial cells. Enhanced expression of elongation factor EF-1 alpha". J. Biol. Chem. 263 (8): 3546–9. PMID 3346208.
Brands JH, Maassen JA, van Hemert FJ; et al. (1986). "The primary structure of the alpha subunit of human elongation factor 1. Structural aspects of guanine-nucleotide-binding sites". Eur. J. Biochem. 155 (1): 167–71. PMID 3512269.

Pranala luar

Video and text from a PBS documentary about the discovery of CCR5
IUPHAR GPCR Database - CCR5 Chemokine Receptor
fact sheet: CCR5 receptor gene and HIV infection at CDC - (note, author is not a CDC employee, and there is no public domain notice on the page, so this cannot be assumed to be public domain)
http://www.cdc.gov/genomics/hugenet/factsheets/FS_CCR5.htm 2% African American show CCR5 indicating extremely recent origin. Smallpox initiator suspect.
Schering-Plough Initiates Phase III Studies with CCR5-Vicriviroc in Treatment- Experienced HIV Patients.

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