SCARB1

SCARB1
Identifiants
Aliases	SCARB1
IDs externes	OMIM: 601040 MGI: 893578 HomoloGene: 21132 GeneCards: SCARB1
Position du gène (Homme)
Chr.	Chromosome 12 humain
Fin	124,882,668 bp
Position du gène (Souris)
Chr.	Chromosome 5 (souris)
Fin	125,418,158 bp
Expression génique
	Fortement exprimé dans
	right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; right lobe of liver; ; left ovary; ; right ovary; ; putamen; ; noyau caudé; ; subcutaneous adipose tissue; ; placenta;
	Fortement exprimé dans
	glande surrénale; ; cumulus cell; ; épithélium pigmentaire rétinien; ; crête génitale; ; artère carotide externe; ; artère carotide interne; ; neural layer of retina; ; lactiferous gland; ; Vésicule vitelline; ; corps ciliaire;
	Plus de données d'expression de référence
	; ;
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	apolipoprotein binding; protein homodimerization activity; virus receptor activity; transporter activity; high-density lipoprotein particle receptor activity; phosphatidylserine binding; apolipoprotein A-I binding; lipopolysaccharide binding; low-density lipoprotein particle binding; 1-phosphatidylinositol binding; liaison protéique; high-density lipoprotein particle binding; lipopolysaccharide immune receptor activity; amyloid-beta binding; scavenger receptor activity;
Composant cellulaire	cytoplasme; integral component of membrane; endocytic vesicle membrane; intracellular membrane-bounded organelle; membrane; membrane plasmique; integral component of plasma membrane; surface cellulaire; lysosomal membrane; cavéole; exosome; microvillus membrane;
Processus biologique	cholesterol import; positive regulation of triglyceride biosynthetic process; regulation of phosphatidylcholine catabolic process; recognition of apoptotic cell; lipid transport; low-density lipoprotein particle clearance; blood vessel endothelial cell migration; positive regulation of cholesterol storage; phospholipid transport; cholesterol transport; cicatrisation; cholesterol catabolic process; endocytose à récepteur; high-density lipoprotein particle remodeling; positive regulation of endothelial cell migration; androgen biosynthetic process; vitamin transmembrane transport; positive regulation of nitric-oxide synthase activity; endothelial cell proliferation; lipopolysaccharide transport; cholesterol efflux; phagocytosis, recognition; pénétration virale; absorption intestinale; cholesterol homeostasis; regulation of phagocytosis; adhesion of symbiont to host; viral process; detection of lipopolysaccharide; triglyceride homeostasis; reverse cholesterol transport; lipopolysaccharide-mediated signaling pathway; high-density lipoprotein particle clearance;
	Sources:Amigo / QuickGO
Orthologues
	949
	20778
	ENSG00000073060
	ENSMUSG00000037936
	Q8WTV0
	Q61009
	NM_005505; NM_001082959
	NM_001205082; NM_001205083; NM_016741
NP_001076428; NP_005496; NP_001354910; NP_001354911; NP_001354912;
	NP_001354913; NP_001354914; NP_001354915; NP_001354916; NP_001354917; NP_001354918
	NP_001192011; NP_001192012; NP_058021
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

Le SCARB1 (pour « Scavenger receptor class B type 1 »), ou SR-BI, est une protéine impliqué dans le métabolisme du cholestérol. Son gène est SCARB1 situé sur le chromosome 12 humain.

Rôles

Il s'agit d'un récepteur au HDL cholestérol situé principalement au niveau du foie^[5], permettant l'élimination de ce dernier et le relargage du cholestérol dans la bile^[6].

En médecine

La mutation du gène entraîne une augmentation du taux sanguin du HDL-cholestérol^[7] mais sans modification du risque de maladie cardio-vasculaire^[8].

Notes et références

↑ ^{a b et c} GRCh38: Ensembl release 89: ENSG00000073060 - Ensembl, May 2017
↑ ^{a b et c} GRCm38: Ensembl release 89: ENSMUSG00000037936 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ Acton S, Rigotti A, Landschulz KT, Xu S, Hobbs HH, Krieger M, Identification of scavenger receptor SR-BI as a high density lipoprotein receptor, Science, 1996;271:518–520
↑ Kozarsky KF, Donahee MH, Rigotti A, Iqbal SN, Edelman ER, Krieger M, Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels, Nature, 1997;387:414–417
↑ Vergeer M, Korporaal SJA, Franssen R et al. Genetic variant of the scavenger receptor BI in humans, N Engl J Med, 2011;364:136–145
↑ Helgadottir A, Sulem P, Thorgeirsson G et al. Rare SCARB1 mutations associate with high-density lipoprotein cholesterol but not with coronary artery disease, Europ Heart J, 2018;39:2179–2182

[refGRCh38Ensembl-1] {a b et c} GRCh38: Ensembl release 89: ENSG00000073060 - Ensembl, May 2017

[refGRCm38Ensembl-2] {a b et c} GRCm38: Ensembl release 89: ENSMUSG00000037936 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[Acton_1996-5] Acton S, Rigotti A, Landschulz KT, Xu S, Hobbs HH, Krieger M, Identification of scavenger receptor SR-BI as a high density lipoprotein receptor, Science, 1996;271:518–520

[Kozarsky_1997-6] Kozarsky KF, Donahee MH, Rigotti A, Iqbal SN, Edelman ER, Krieger M, Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels, Nature, 1997;387:414–417

[Vergeer_2011-7] Vergeer M, Korporaal SJA, Franssen R et al. Genetic variant of the scavenger receptor BI in humans, N Engl J Med, 2011;364:136–145

[Helgadottir_2018-8] Helgadottir A, Sulem P, Thorgeirsson G et al. Rare SCARB1 mutations associate with high-density lipoprotein cholesterol but not with coronary artery disease, Europ Heart J, 2018;39:2179–2182

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