Afinina

Afinina
Formula kimikoa	C20H24N2O2
SMILES kanonikoa	2D eredua
SMILES isomerikoa	C/C=C\1/CN([C@@H]2CC3=C(C(=O)C[C@H]1C2CO)NC4=CC=CC=C34)C
MolView	3D eredua
Mota	vobasine alkaloid (en)
Masa molekularra	324,183778 Da
Identifikatzaileak
InChlKey	PXFBZOLANLWPMH-SMLHJDAJSA-N
CAS zenbakia	2134-82-9
ChemSpider	4444714
PubChem	5281345
Gmelin	2502
KNApSAcK	C00001675
KEGG	C09021

Afinina alkaloide indol monoterpenoide bat da, Tabernaemontana generoko landareetatik isolatu daitekeena^[1]^[2]. Egitura aldetik, bobasina alkaloideen familiako da, eta baliteke triptofanotik sintetizatu ahal izatea^[3]. Test farmakologiko gutxi egin dira, baina baliteke azetilkolinesterasaren eta buririlkolinesterasaren inhibitzaile eraginkorra izatea^[4].

Erreferentziak

↑ Weisbach, Jerry A.; Raffauf, Robert F.; Ribeiro, Oscar; Macko, Edward; Douglas, Bryce. (1963-04). «Problems in Chemotaxonomy I» Journal of Pharmaceutical Sciences 52 (4): 350–353. doi:10.1002/jps.2600520408. ISSN 0022-3549. (Noiz kontsultatua: 2020-08-31).
↑ (Ingelesez) Monnerat, Cecilia Silva; Souza, Jucimar Jorgeane de; Mathias, Leda; Braz-Filho, Raimundo; Vieira, Ivo José C.. (2005-11). «A new indole alkaloid isolated from Tabernaemontana hystrix steud (Apocynaceae)» Journal of the Brazilian Chemical Society 16 (6B): 1331–1335. doi:10.1590/S0103-50532005000800004. ISSN 0103-5053. (Noiz kontsultatua: 2020-08-31).
↑ (Ingelesez) Yang, Jie; Rallapalli, Sundari K.; Cook, James M.. (2010-02-03). «The first enantiospecific total synthesis of the 3-oxygenated sarpagine indole alkaloids affinine and 16-epiaffinine, as well as vobasinediol and 16-epivobasinediol» Tetrahedron Letters 51 (5): 815–817. doi:10.1016/j.tetlet.2009.12.002. ISSN 0040-4039. (Noiz kontsultatua: 2020-08-31).
↑ (Ingelesez) Vieira, Ivo J. C.; Medeiros, Walter L. B.; Monnerat, Cecilia S.; Souza, Jucimar J.; Mathias, Leda; Braz-Filho, Raimundo; Pinto, Angelo C.; Sousa, Priscila M. et al.. (2008-09). «Two fast screening methods (GC-MS and TLC-ChEI assay) for rapid evaluation of potential anticholinesterasic indole alkaloids in complex mixtures» Anais da Academia Brasileira de Ciências 80 (3): 419–426. doi:10.1590/S0001-37652008000300003. ISSN 0001-3765. (Noiz kontsultatua: 2020-08-31).

Kanpo estekak

Datuak: Q15410234

[1] Weisbach, Jerry A.; Raffauf, Robert F.; Ribeiro, Oscar; Macko, Edward; Douglas, Bryce. (1963-04). «Problems in Chemotaxonomy I» Journal of Pharmaceutical Sciences 52 (4): 350–353. doi:10.1002/jps.2600520408. ISSN 0022-3549. (Noiz kontsultatua: 2020-08-31).

[2] (Ingelesez) Monnerat, Cecilia Silva; Souza, Jucimar Jorgeane de; Mathias, Leda; Braz-Filho, Raimundo; Vieira, Ivo José C.. (2005-11). «A new indole alkaloid isolated from Tabernaemontana hystrix steud (Apocynaceae)» Journal of the Brazilian Chemical Society 16 (6B): 1331–1335. doi:10.1590/S0103-50532005000800004. ISSN 0103-5053. (Noiz kontsultatua: 2020-08-31).

[3] (Ingelesez) Yang, Jie; Rallapalli, Sundari K.; Cook, James M.. (2010-02-03). «The first enantiospecific total synthesis of the 3-oxygenated sarpagine indole alkaloids affinine and 16-epiaffinine, as well as vobasinediol and 16-epivobasinediol» Tetrahedron Letters 51 (5): 815–817. doi:10.1016/j.tetlet.2009.12.002. ISSN 0040-4039. (Noiz kontsultatua: 2020-08-31).

[4] (Ingelesez) Vieira, Ivo J. C.; Medeiros, Walter L. B.; Monnerat, Cecilia S.; Souza, Jucimar J.; Mathias, Leda; Braz-Filho, Raimundo; Pinto, Angelo C.; Sousa, Priscila M. et al.. (2008-09). «Two fast screening methods (GC-MS and TLC-ChEI assay) for rapid evaluation of potential anticholinesterasic indole alkaloids in complex mixtures» Anais da Academia Brasileira de Ciências 80 (3): 419–426. doi:10.1590/S0001-37652008000300003. ISSN 0001-3765. (Noiz kontsultatua: 2020-08-31).

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