Talk:Alkylation

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These article really needs some examples drawn out. See the Grignard reagents article- full of pictures showing how it works and when it happens.

I don't think a reaction chamber is the proper image for an article on the type of chemical reaction that takes place inside it. Especially when it's the only image.

Giving notice that I intend to merge alkylating agent with alkylation because of the huge overlap in terms of content. Comments for and against? --Rifleman 82 15:50, 27 June 2007 (UTC)[reply]

It's disappointing that this article (prior to the edit I'm about to make) deals with alkylating agents solely as cancer drugs and makes that sound like their main use, even though it's only a tiny fraction - the overwhelmingly larger use being in chemical manufacturing. Unfortunately, I don't have a lot of material to add on that myself, but it would be nice if the material could be found and added. 216.59.230.140 01:30, 16 December 2006 (UTC)[reply]

The medical content is now split out. --Arcadian 19:12, 8 March 2007 (UTC)[reply]

See second sentence of this article.--Smokefoot 17:34, 31 December 2006 (UTC)[reply]

If that's true, then the phosgene article should be updated. I'm not sure it is true, though; phosgene is a popular reagent in alkylation reactions even if the alkyl has to come from another reagent. It doesn't have to be the donor to be important in the reaction; by the same token, Raney nickel is a hydrogenating agent even though it doesn't donate the hydrogen. This peer-reviewed scholarly article, unfortunately not available for free on the Web, refers to phosgene as an alkylating agent:

Venkatesan C., Singh A.P. Selective Mono-Methylation of Phenylacetonitrile to 2-Phenyl Propionitrile over 3-Aminopropylsilyl Functionalized MCM-41. Catalysis Letters, Volume 80, Numbers 1-2, May 2002, pp. 7-10(4). Springer.

They write (first sentence of the paper; internal citation omitted): "Since mono-methylated arylacetonitriles are important precursors of 2-arylpropionic acids, the well-known anti-inflammatory drugs, the alkylation of phenylacetonitrile (PAN) under safe conditions and with non-toxic alkylating agents instead of toxic and corrosive alkylating agents such as phosgene, dimethylsulfate and methyl iodide is of interest." 216.59.230.140 15:31, 7 January 2007 (UTC)[reply]

Perhaps a few examples of the most common alkylating agents (e.g. Grignard) would be good? I'd add them myself, except that I'm suffering a complete lack of memory today, which is why I'm on this page in the first place. Mullet 12:01, 22 April 2007 (UTC)[reply]

I start to believe a new article should be created. The existing paragraph is getting too long. --Silvio1973 (talk) 10:19, 8 November 2012 (UTC)[reply]

Vitamin B12-derived cofactors are NOT the primary source of methylation events in biology. S-adensoylmethionine is the activated cofactor that acts as a methyl donor in the majority of enzyme catalyzed reactions.24.141.62.173 (talk) 03:42, 6 February 2014 (UTC)[reply]

Today, I've marked "C_n", where n is "4", "7" or "8", as requiring further clarification. I'm guessing (as a non-chemical engineer) that these refer to organic compounds, specifically some types likely to be found in oil refining, that are hydrocarbons (probably straight-chain) with the specified number n of carbon atoms in the molecule. Your average reader may even make a worse guess than this! Please help make this understandable to the interested layperson. yoyo (talk) 03:50, 5 January 2016 (UTC)[reply]

The following Wikimedia Commons file used on this page has been nominated for deletion:

• Sodium dodecylbenzenesulfonate.png

Participate in the deletion discussion at the nomination page. —Community Tech bot (talk) 17:50, 5 November 2018 (UTC)[reply]