CDKN3

CDKN3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FPZ, 1FQ1
Identifiers
Aliases	CDKN3, CDI1, CIP2, KAP, KAP1, cyclin-dependent kinase inhibitor 3, cyclin dependent kinase inhibitor 3, CDLN3
External IDs	OMIM: 123832; MGI: 1919641; HomoloGene: 3805; GeneCards: CDKN3; OMA:CDKN3 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	54,420,218 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	47,009,126 bp
RNA expression pattern
	Top expressed in
	left testis; ; sperm; ; right testis; ; ventricular zone; ; gonad; ; ganglionic eminence; ; testicle; ; buccal mucosa cell; ; bone marrow; ; trabecular bone;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; yolk sac; ; otic vesicle; ; ventricular zone; ; medial ganglionic eminence; ; lumbar spinal ganglion; ; genital tubercle; ; granulocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatase activity; protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity; hydrolase activity; protein binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity;
Cellular component	nucleus; perinuclear region of cytoplasm; cytoplasm; cytosol;
Biological process	cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of cell population proliferation; dephosphorylation; peptidyl-tyrosine dephosphorylation; protein dephosphorylation; G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	1033
	72391
	ENSG00000100526
	ENSMUSG00000037628
	Q16667
	Q810P3
	NM_001130851; NM_005192; NM_001330173
	NM_028222; NM_001360041
	NP_001124323; NP_001317102; NP_005183
	NP_082498; NP_001346970
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin-dependent kinase inhibitor 3 is an enzyme that in humans is encoded by the CDKN3 gene.^[5]^[6]^[7]

The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers.^[7]

Interactions

CDKN3 has been shown to interact with Cyclin-dependent kinase 2,^[8]^[9]^[10] Cdk1^[5]^[9] and MS4A3.^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100526 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037628 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Gyuris J, Golemis E, Chertkov H, Brent R (Dec 1993). "Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2". Cell. 75 (4): 791–803. doi:10.1016/0092-8674(93)90498-F. PMID 8242750.
^ Demetrick DJ, Matsumoto S, Hannon GJ, Okamoto K, Xiong Y, Zhang H, Beach DH (May 1995). "Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)". Cytogenet Cell Genet. 69 (3–4): 190–2. doi:10.1159/000133960. PMID 7698009.
^ ^a ^b "Entrez Gene: CDKN3 cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)".
^ Yeh CT, Lu Su-Chuan, Chao Chung-Hao, Chao Mei-Ling (May 2003). "Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant". Biochem. Biophys. Res. Commun. 305 (2): 311–4. doi:10.1016/S0006-291X(03)00757-5. ISSN 0006-291X. PMID 12745075.
^ ^a ^b Hannon GJ, Casso D, Beach D (Mar 1994). "KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases". Proc. Natl. Acad. Sci. U.S.A. 91 (5): 1731–5. Bibcode:1994PNAS...91.1731H. doi:10.1073/pnas.91.5.1731. ISSN 0027-8424. PMC 43237. PMID 8127873.
^ Harper JW, Adami G R, Wei N, Keyomarsi K, Elledge S J (Nov 1993). "The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases". Cell. 75 (4): 805–16. doi:10.1016/0092-8674(93)90499-G. ISSN 0092-8674. PMID 8242751. S2CID 13614794.
^ Donato JL, Ko Jon, Kutok Jeffery L, Cheng Tao, Shirakawa Taro, Mao Xiao-Quan, Beach David, Scadden David T, Sayegh Mohamed H, Adra Chaker N (Jan 2002). "Human HTm4 is a hematopoietic cell cycle regulator". J. Clin. Invest. 109 (1): 51–8. doi:10.1172/JCI14025. ISSN 0021-9738. PMC 150822. PMID 11781350.

External links

CDKN3 human gene location in the UCSC Genome Browser.
CDKN3 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100526 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037628 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8242750-5] Gyuris J, Golemis E, Chertkov H, Brent R (Dec 1993). "Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2". Cell. 75 (4): 791–803. doi:10.1016/0092-8674(93)90498-F. PMID 8242750.

[pmid7698009-6] Demetrick DJ, Matsumoto S, Hannon GJ, Okamoto K, Xiong Y, Zhang H, Beach DH (May 1995). "Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)". Cytogenet Cell Genet. 69 (3–4): 190–2. doi:10.1159/000133960. PMID 7698009.

[entrez-7] "Entrez Gene: CDKN3 cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)".

[pmid12745075-8] Yeh CT, Lu Su-Chuan, Chao Chung-Hao, Chao Mei-Ling (May 2003). "Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant". Biochem. Biophys. Res. Commun. 305 (2): 311–4. doi:10.1016/S0006-291X(03)00757-5. ISSN 0006-291X. PMID 12745075.

[pmid8127873-9] Hannon GJ, Casso D, Beach D (Mar 1994). "KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases". Proc. Natl. Acad. Sci. U.S.A. 91 (5): 1731–5. Bibcode:1994PNAS...91.1731H. doi:10.1073/pnas.91.5.1731. ISSN 0027-8424. PMC 43237. PMID 8127873.

[pmid8242751-10] Harper JW, Adami G R, Wei N, Keyomarsi K, Elledge S J (Nov 1993). "The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases". Cell. 75 (4): 805–16. doi:10.1016/0092-8674(93)90499-G. ISSN 0092-8674. PMID 8242751. S2CID 13614794.

[pmid11781350-11] Donato JL, Ko Jon, Kutok Jeffery L, Cheng Tao, Shirakawa Taro, Mao Xiao-Quan, Beach David, Scadden David T, Sayegh Mohamed H, Adra Chaker N (Jan 2002). "Human HTm4 is a hematopoietic cell cycle regulator". J. Clin. Invest. 109 (1): 51–8. doi:10.1172/JCI14025. ISSN 0021-9738. PMC 150822. PMID 11781350.

[1]

Interactions

References

Further reading

External links