Afridi is a surname. Notable people with the surname include:
- Ashfaq Afridi (born 1987), Pakistani cricketer
- Ayub Afridi (drug lord), Pakistani drug lord
- Ayub Afridi (politician), Pakistani senator
- Latif Afridi (born 1943), Pakistani lawyer and politician
- Khatir Afridi (born 1929), Pakistani poet
- Shaheen Afridi (born 2000), Pakistani cricketer
- Shahid Afridi, Pakistani cricketer
- Shakil Afridi, Pakistani physician who allegedly helped the CIA locate Osama bin Laden
- Shehryar Khan Afridi, Pakistani politician
- Zeek Afridi, Pakistani singer