Growth-Factor-Driven Rescue to Receptor Tyrosine Kinase (RTK) Inhibitors through Akt and Erk Phosphorylation in Pediatric Low Grade Astrocytoma and Ependymoma
Fig 6
Cell monolayers were scratched with a pipette tip to produce a clear cell-free area into which cells at the periphery could migrate. Micrographs showing migrated Res-259 cells treated with DMSO (control), the effect on tumor cell migration of HGF (100 ng/ml), canertinib (2 uM), HGF addition to canertinib and the combination treatment including canertinib and crizotinib (3 uM) after 24h (upper panels) and 48h (lower panels).