TXN

TXN
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4TRX, 1AIU, 1AUC, 1CQG, 1CQH, 1ERT, 1ERU, 1ERV, 1ERW, 1MDI, 1MDJ, 1MDK, 1TRS, 1TRU, 1TRV, 1TRW, 2HSH, 2HXK, 2IFQ, 2IIY, 3E3E, 3KD0, 3M9J, 3M9K, 3QFA, 3QFB, 3TRX, 4LL1, 4LL4, 4OO4, 4OO5, 4POK, 4POL, 4POM, 4PUF, 5DQY
Dynodwyr
Cyfenwau	TXN, TRDX, TRX, TRX1, thioredoxin, Trx80
Dynodwyr allanol	OMIM: 187700 HomoloGene: 128202 GeneCards: TXN
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein-disulfide reductase activity • oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor • GO:0001948, GO:0016582 protein binding • thioredoxin-disulfide reductase activity • protein-disulfide reductase (NAD(P)) activity • RNA binding Cydrannau o'r gell • extracellular region • extracellular exosome • cnewyllyn cell • cytoplasm • mitocondria • cytosol • nucleoplasm Prosesau biolegol • activation of protein kinase B activity • positive regulation of protein kinase B signaling • nucleobase-containing small molecule interconversion • glycerol ether metabolic process • GO:0009373 regulation of transcription, DNA-templated • cell-cell signaling • GO:1901227 negative regulation of transcription by RNA polymerase II • cell redox homeostasis • transcription, DNA-templated • positive regulation of peptidyl-serine phosphorylation • negative regulation of protein export from nucleus • response to radiation • positive regulation of DNA binding • negative regulation of hydrogen peroxide-induced cell death • cell population proliferation • GO:0072468 signal transduction • protein repair • cellular oxidant detoxification • cellular response to oxidative stress Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7295	n/a
Ensembl	ENSG00000136810	n/a
UniProt	P10599	n/a
RefSeq (mRNA)	NM_003329 NM_001244938	n/a
RefSeq (protein)	NP_001231867 NP_003320	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TXN yw TXN a elwir hefyd yn Thioredoxin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 9, band 9q31.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TXN.

• TRX
• TRDX
• TRX1

• "Serum thioredoxin and in-hospital major adverse events after traumatic brain injury. ". Clin Chim Acta. 2017. PMID 28347674.
• "Serum and urinary thioredoxin concentrations are associated with severity of children hydronephrosis. ". Clin Chim Acta. 2017. PMID 28111273.
• "Postoperative serum thioredoxin concentrations correlate with delirium and cognitive dysfunction after hip fracture surgery in elderly patients. ". Clin Chim Acta. 2017. PMID 28093200.
• "Thioredoxin and redox signaling: Roles of the thioredoxin system in control of cell fate. ". Arch Biochem Biophys. 2017. PMID 27665998.
• "Expression of thioredoxin-1 (TXN) and its relation with oxidative DNA damage and treatment outcome in adult AML and ALL: A comparative study.". Hematology. 2016. PMID 27158980.