TDP1

TDP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1JY1, 1MU7, 1MU9, 1NOP, 1QZQ, 1RFF, 1RFI, 1RG1, 1RG2, 1RGT, 1RGU, 1RH0
Dynodwyr
Cyfenwau	TDP1, tyrosyl-DNA phosphodiesterase 1
Dynodwyr allanol	OMIM: 607198 HomoloGene: 5424 GeneCards: TDP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phosphoric diester hydrolase activity • single-stranded DNA binding • nuclease activity • double-stranded DNA binding • 3'-tyrosyl-DNA phosphodiesterase activity • exonuclease activity • GO:0001948, GO:0016582 protein binding • hydrolase activity Cydrannau o'r gell • cytoplasm • Cellbilen • intracellular membrane-bounded organelle • cnewyllyn cell Prosesau biolegol • single strand break repair • double-strand break repair • GO:0100026 DNA repair • nucleic acid phosphodiester bond hydrolysis • cellular response to DNA damage stimulus Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	55775	n/a
Ensembl	ENSG00000042088	n/a
UniProt	Q9NUW8	n/a
RefSeq (mRNA)	NM_001008744 NM_018319 NM_001330205	n/a
RefSeq (protein)	NP_001008744 NP_001317134 NP_060789	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TDP1 yw TDP1 a elwir hefyd yn Tyrosyl-DNA phosphodiesterase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q32.11.^[2]

• "TDP1 promotes assembly of non-homologous end joining protein complexes on DNA. ". DNA Repair (Amst). 2015. PMID 25841101.
• "Tyrosyl-DNA phosphodiesterase I catalytic mutants reveal an alternative nucleophile that can catalyze substrate cleavage. ". J Biol Chem. 2015. PMID 25609251.
• "TDP1 is Critical for the Repair of DNA Breaks Induced by Sapacitabine, a Nucleoside also Targeting ATM- and BRCA-Deficient Tumors. ". Mol Cancer Ther. 2017. PMID 28802254.
• "Tyrosyl-DNA-phosphodiesterase I (TDP1) participates in the removal and repair of stabilized-Top2α cleavage complexes in human cells. ". Mutat Res. 2015. PMID 26421495.
• "A Theoretical Study of Phosphoryl Transfers of Tyrosyl-DNA Phosphodiesterase I (Tdp1) and the Possibility of a "Dead-End" Phosphohistidine Intermediate.". Biochemistry. 2015. PMID 26121557.