TAF4

TAF4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1H3O, 2P6V
Dynodwyr
Cyfenwau	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135, TATA-box binding protein associated factor 4, TAFII-135, TAFII-130, TAF(II)135, TAF(II)130
Dynodwyr allanol	OMIM: 601796 HomoloGene: 55723 GeneCards: TAF4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001105 transcription coactivator activity • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • aryl hydrocarbon receptor binding • transcription factor binding • GO:0000983 RNA polymerase II general transcription initiation factor activity Cydrannau o'r gell • transcription factor TFTC complex • transcription factor TFIID complex • nucleoplasm • MLL1 complex • cnewyllyn cell • cytosol • GO:0009327 protein-containing complex Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • DNA-templated transcription, initiation • ovarian follicle development • transcription initiation from RNA polymerase II promoter • regulation of signal transduction by p53 class mediator • GO:0022415 viral process • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • RNA polymerase II preinitiation complex assembly Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6874	n/a
Ensembl	ENSG00000130699	n/a
UniProt	O00268	n/a
RefSeq (mRNA)	NM_003185	n/a
RefSeq (protein)	NP_003176	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TAF4 yw TAF4 a elwir hefyd yn TATA-box binding protein associated factor 4 a Transcription initiation factor TFIID subunit 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 20, band 20q13.33.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TAF4.

• "The coactivator dTAF(II)110/hTAF(II)135 is sufficient to recruit a polymerase complex and activate basal transcription mediated by CREB. ". Proc Natl Acad Sci U S A. 2001. PMID 11687654.
• "Human TAF(II)135 potentiates transcriptional activation by the AF-2s of the retinoic acid, vitamin D3, and thyroid hormone receptors in mammalian cells. ". Genes Dev. 1997. PMID 9192867.
• "TAF4 controls differentiation of human neural progenitor cells through hTAF4-TAFH activity. ". J Mol Neurosci. 2015. PMID 24696168.
• "Alternative splicing targeting the hTAF4-TAFH domain of TAF4 represses proliferation and accelerates chondrogenic differentiation of human mesenchymal stem cells. ". PLoS One. 2013. PMID 24098348.
• "A role of the TATA box and the general co-activator hTAF(II)130/135 in promoter-specific trans-activation by simian virus 40 small t antigen.". J Gen Virol. 2003. PMID 12810884.