POLM

POLM
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2HTF, 4LZD, 4M04, 4M0A, 4YCX, 4YD1, 4YD2, 2DUN
Dynodwyr
Cyfenwau	POLM, Pol Mu, Tdt-N, DNA polymerase mu, polymerase (DNA) mu
Dynodwyr allanol	OMIM: 606344 HomoloGene: 41170 GeneCards: POLM
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • DNA binding • DNA-directed DNA polymerase activity • nucleotidyltransferase activity • GO:0001948, GO:0016582 protein binding • metal ion binding • DNA polymerase • DNA polymerase activity Cydrannau o'r gell • cnewyllyn cell • nucleoplasm Prosesau biolegol • somatic hypermutation of immunoglobulin genes • B cell differentiation • DNA recombination • double-strand break repair via nonhomologous end joining • cellular response to DNA damage stimulus • GO:0100026 DNA repair • DNA biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	27434	n/a
Ensembl	ENSG00000122678	n/a
UniProt	Q9NP87	n/a
RefSeq (mRNA)	NM_001284330 NM_001284331 NM_013284 NM_001362683	n/a
RefSeq (protein)	NP_001271259 NP_001271260 NP_037416 NP_001349612	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn POLM yw POLM a elwir hefyd yn DNA polymerase mu (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7p13.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn POLM.

• Tdt-N
• Pol*Mu

• "Decision-making during NHEJ: a network of interactions in human Polμ implicated in substrate recognition and end-bridging. ". Nucleic Acids Res. 2014. PMID 24878922.
• "Sustained active site rigidity during synthesis by human DNA polymerase μ. ". Nat Struct Mol Biol. 2014. PMID 24487959.
• "Polμ tumor variants decrease the efficiency and accuracy of NHEJ. ". Nucleic Acids Res. 2017. PMID 28973441.
• "Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu. ". Nucleic Acids Res. 2017. PMID 28911097.
• "Creative template-dependent synthesis by human polymerase mu.". Proc Natl Acad Sci U S A. 2015. PMID 26240373.