PLEKHA1

PLEKHA1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1EAZ
Dynodwyr
Cyfenwau	PLEKHA1, TAPP1, pleckstrin homology domain containing A1
Dynodwyr allanol	OMIM: 607772 HomoloGene: 11001 GeneCards: PLEKHA1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • PDZ domain binding • phosphatidylinositol-3,4-bisphosphate binding • GO:0001948, GO:0016582 protein binding • lipid binding Cydrannau o'r gell • cytoplasm • bilen • nucleoplasm • ruffle membrane • extracellular exosome • cnewyllyn cell • cytosol • Cellbilen Prosesau biolegol • B cell receptor signaling pathway • roof of mouth development • negative regulation of protein kinase B signaling • luteinization • Leydig cell differentiation • estrogen metabolic process • androgen metabolic process • ruffle organization • multicellular organism growth • establishment of protein localization • skeletal system morphogenesis • post-embryonic development • female gonad development • spermatogenesis • phosphatidylinositol 3-kinase signaling • platelet-derived growth factor receptor signaling pathway • face morphogenesis • cellular response to hydrogen peroxide • phosphatidylinositol biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	59338	n/a
Ensembl	ENSG00000107679	n/a
UniProt	Q9HB21	n/a
RefSeq (mRNA)	NM_001001974 NM_001195608 NM_021622 NM_001330178	n/a
RefSeq (protein)	NP_001001974 NP_001182537 NP_001317107 NP_067635 NP_001364159 NP_001364160 NP_001364161 NP_001364163 NP_001364164 NP_001364166 NP_001364167 NP_001364169 NP_001364170 NP_001364171 NP_001364172 NP_001364173 NP_001364174 NP_001364175 NP_001364176 NP_001364177 NP_001364178 NP_001364179 NP_001364180 NP_001364181 NP_001364182 NP_001364183 NP_001364184 NP_001364185 NP_001364186 NP_001364187	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PLEKHA1 yw PLEKHA1 a elwir hefyd yn Pleckstrin homology domain-containing family A member 1 a Pleckstrin homology domain containing A1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q26.13.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PLEKHA1.

• TAPP1

• "Cumulative association between age-related macular degeneration and less studied genetic variants in PLEKHA1/ARMS2/HTRA1: a meta and gene-cluster analysis. ". Mol Biol Rep. 2013. PMID 24013816.
• "PLEKHA1-LOC387715-HTRA1 polymorphisms and exudative age-related macular degeneration in the French population. ". Mol Vis. 2007. PMID 18079691.
• "Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity. ". Biochem J. 2001. PMID 11513726.
• "Susceptibility genes for age-related maculopathy on chromosome 10q26. ". Am J Hum Genet. 2005. PMID 16080115.
• "Gene Structure of the 10q26 Locus: A Clue to Cracking the ARMS2/HTRA1 Riddle?". Adv Exp Med Biol. 2016. PMID 26427389.