PLAUR

PLAUR
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1YWH, 2FD6, 3BT1, 3BT2, 3U73, 3U74, 2I9B, 4K24, 4QTI
Dynodwyr
Cyfenwau	PLAUR, CD87, U-PAR, UPAR, URKR, plasminogen activator, urokinase receptor
Dynodwyr allanol	OMIM: 173391 HomoloGene: 48120 GeneCards: PLAUR
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein domain specific binding • GO:0001948, GO:0016582 protein binding • urokinase plasminogen activator receptor activity • enzyme binding • signaling receptor binding • signaling receptor activity Cydrannau o'r gell • integral component of membrane • cell projection • endoplasmic reticulum lumen • endoplasmic reticulum membrane • bilen • focal adhesion • integral component of plasma membrane • extracellular region • cell junction • anchored component of membrane • extracellular exosome • extrinsic component of membrane • Cellbilen • specific granule membrane • cell surface Prosesau biolegol • positive regulation of protein phosphorylation • negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • fibrinolysis • negative regulation of intrinsic apoptotic signaling pathway • urokinase plasminogen activator signaling pathway • negative regulation of apoptotic process • blood coagulation • attachment of GPI anchor to protein • chemotaxis • positive regulation of release of cytochrome c from mitochondria • positive regulation of DNA binding • positive regulation of epidermal growth factor receptor signaling pathway • regulation of proteolysis • GO:0072468 signal transduction • neutrophil degranulation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5329	n/a
Ensembl	ENSG00000011422	n/a
UniProt	Q03405	n/a
RefSeq (mRNA)	NM_001005376 NM_001005377 NM_001301037 NM_002659	n/a
RefSeq (protein)	NP_001005376 NP_001005377 NP_001287966 NP_002650	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PLAUR yw PLAUR a elwir hefyd yn Plasminogen activator, urokinase receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19q13.31.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PLAUR.

• "Association of Serum Soluble Urokinase Receptor Levels With Progression of Kidney Disease in Children. ". JAMA Pediatr. 2017. PMID 28873129.
• "Plasma levels of intact and cleaved urokinase plasminogen activator receptor (uPAR) in men with clinically localised prostate cancer. ". J Clin Pathol. 2017. PMID 28607123.
• "uPAR-targeted optical near-infrared (NIR) fluorescence imaging and PET for image-guided surgery in head and neck cancer: proof-of-concept in orthotopic xenograft model. ". Oncotarget. 2017. PMID 28039488.
• "Soluble urokinase-type plasminogen activator receptor (suPAR) in patients with acute pancreatitis (AP) - Progress in prediction of AP severity. ". Pancreatology. 2017. PMID 27914940.
• "mTORC2 activation is regulated by the urokinase receptor (uPAR) in bladder cancer.". Cell Signal. 2017. PMID 27777073.