MSX1

MSX1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1IG7
Dynodwyr
Cyfenwau	MSX1, ECTD3, HOX7, HYD1, STHAG1, msh homeobox 1
Dynodwyr allanol	OMIM: 142983 HomoloGene: 1836 GeneCards: MSX1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • sequence-specific DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • p53 binding • DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • nucleoplasm • cnewyllyn cell Prosesau biolegol • anterior/posterior pattern specification • negative regulation of cell population proliferation • negative regulation of striated muscle cell differentiation • signal transduction involved in regulation of gene expression • regulation of odontogenesis • negative regulation of transcription regulatory region DNA binding • stem cell differentiation • positive regulation of mesenchymal cell apoptotic process • mammary gland epithelium development • negative regulation of apoptotic process • activation of meiosis • positive regulation of BMP signaling pathway • transcription, DNA-templated • cartilage morphogenesis • positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator • multicellular organism development • odontogenesis • bone morphogenesis • embryonic limb morphogenesis • BMP signaling pathway • middle ear morphogenesis • mesenchymal cell proliferation • embryonic forelimb morphogenesis • negative regulation of DNA binding • positive regulation of DNA damage response, signal transduction by p53 class mediator • heart morphogenesis • BMP signaling pathway involved in heart development • GO:0000767 cell morphogenesis • heart development • forebrain development • muscle organ development • GO:1901227 negative regulation of transcription by RNA polymerase II • roof of mouth development • embryonic digit morphogenesis • in utero embryonic development • protein stabilization • GO:0009373 regulation of transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • epithelial to mesenchymal transition involved in endocardial cushion formation • transcription by RNA polymerase II • negative regulation of cell growth • epithelial to mesenchymal transition • embryonic hindlimb morphogenesis • GO:0045996 negative regulation of transcription, DNA-templated • protein localization to nucleus • midbrain development • odontogenesis of dentin-containing tooth • embryonic nail plate morphogenesis • face morphogenesis • pituitary gland development • cellular response to nicotine • cartilage development • embryonic morphogenesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4487	n/a
Ensembl	ENSG00000163132	n/a
UniProt	P28360	n/a
RefSeq (mRNA)	NM_002448	n/a
RefSeq (protein)	NP_002439	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MSX1 yw MSX1 a elwir hefyd yn Msh homeobox 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4p16.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MSX1.

• "MSX1 gene polymorphisms in Mexican patients with non-syndromic cleft lip/palate. ". Int J Pediatr Otorhinolaryngol. 2016. PMID 27729116.
• "A novel MSX1 intronic mutation associated with autosomal dominant non-syndromic oligodontia in a large Chinese family pedigree. ". Clin Chim Acta. 2016. PMID 27485761.
• "MSX1 mutations and associated disease phenotypes: genotype-phenotype relations. ". Eur J Hum Genet. 2016. PMID 27381090.
• "Mutations in MSX1, PAX9 and MMP20 genes in Saudi Arabian patients with tooth agenesis. ". Eur J Med Genet. 2016. PMID 27365112.
• "Association of MSX1 c.*6C > T Variant with Nonsyndromic Cleft Lip With or Without Cleft Palate in Turkish Patients.". Genet Test Mol Biomarkers. 2016. PMID 27228008.