MAX

MAX
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1AN2, 1HLO, 1NKP, 1NLW, 1R05
Dynodwyr
Cyfenwau	MAX, bHLHd4, max, MYC associated factor X
Dynodwyr allanol	OMIM: 154950 HomoloGene: 1786 GeneCards: MAX
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • sequence-specific DNA binding • protein dimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001105 transcription coactivator activity • GO:0001104 transcription coregulator activity • GO:0000983 RNA polymerase II general transcription initiation factor activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • DNA binding • protein homodimerization activity • E-box binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0032403 protein-containing complex binding • protein heterodimerization activity Cydrannau o'r gell • PML body • cell projection • dendrite • cnewyllyn cell • nucleoplasm • cytoplasm • protein-DNA complex • MLL1 complex • RNA polymerase II transcription regulator complex Prosesau biolegol • neuron apoptotic process • GO:0009373 regulation of transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • cellular response to starvation • transcription by RNA polymerase II • negative regulation of gene expression • transcription, DNA-templated • response to insulin • cellular response to peptide hormone stimulus • retina development in camera-type eye • response to axon injury • response to organonitrogen compound • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of G0 to G1 transition • G1/S transition of mitotic cell cycle • GO:0034622 protein-containing complex assembly • positive regulation of nucleic acid-templated transcription • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4149	n/a
Ensembl	ENSG00000125952	n/a
UniProt	P61244 Q8TAX8	n/a
RefSeq (mRNA)	NM_001271068 NM_001271069 NM_002382 NM_145112 NM_145113 NM_145114 NM_145116 NM_197957 NM_001320415	n/a
RefSeq (protein)	NP_001257997 NP_001257998 NP_001307344 NP_002373 NP_660087 NP_660088 NP_660089 NP_932061 NP_002373.3 NP_660087.1 NP_660088.1 NP_001307344.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAX yw MAX a elwir hefyd yn MYC associated factor X (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 14, band 14q23.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAX.

• bHLHd4

• "Biophysical characterization of the b-HLH-LZ of ΔMax, an alternatively spliced isoform of Max found in tumor cells: Towards the validation of a tumor suppressor role for the Max homodimers. ". PLoS One. 2017. PMID 28350847.
• "MAX is an epigenetic sensor of 5-carboxylcytosine and is altered in multiple myeloma. ". Nucleic Acids Res. 2017. PMID 27903915.
• "Social stress in adolescents induces depression and brain-region-specific modulation of the transcription factor MAX. ". Transl Psychiatry. 2016. PMID 27727240.
• "Complex MAX Rearrangement in a Family With Malignant Pheochromocytoma, Renal Oncocytoma, and Erythrocytosis. ". J Clin Endocrinol Metab. 2016. PMID 26670126.
• "Functional and in silico assessment of MAX variants of unknown significance.". J Mol Med (Berl). 2015. PMID 26070438.